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Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers

Mulvihill, John J.E.; Cunnane, Eoghan M.; Ross, Aisling M.; Duskey, Jason T.; Tosi, Giovanni; Grabrucker, Andreas M. (Future Medicine, 2020)

The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome ...
Nanotoxicology data for in silico tools: a literature review

Furxhi, Irini; Murphy, Finbarr; Mullins, Martin; Arvanitis, Athanasios; Poland, Craig A. (Taylor and Francis, 2020)

The exercise of non-testing approaches in nanoparticles (NPs) hazard assessment is necessary for the risk assessment, considering cost and time efficiency, to identify, assess, and classify potential risks. One strategy ...
Efficacy of viral load suppression on life expectancy of human immunodeficiency virus patients: a literature review

Bwambale Kyamakya, Moses; Niranjan, Vikram (Medip Academy, 2020)

In a bid mitigate the spread of HIV and AIDS since it was diagnosed, several interventions ranging from palliative care, increased access to HIV treatment to manage opportunistic infections and the current drive of improving ...
Simulation of biopsy bevel-tipped needle insertion into soft-gel

Jushiddi, Mohamed Gouse; Mulvihill, John J.E.; Chovan, Drahomir; Mani, Aladin; Shanahan, Camelia; Silien, Christophe; Tofail, Syed A.M.; Tiernan, Peter (Elsevier, 2019)

Planning and practice of surgical procedures can be improved through the use of modelling. This study provides an insight into the biopsy needle (i.e. hollow cannula) and needle-tissue interactions using a modelling approach, ...
Neuro-Fuzzy dynamic position prediction for autonomous work-class ROV docking

Trslić, Petar; Omerdic, Edin; Dooly, Gerard; Toal, Daniel (MDPI, 2020)

This paper presents a docking station heave motion prediction method for dynamic remotely operated vehicle (ROV) docking, based on the Adaptive Neuro-Fuzzy Inference System (ANFIS). Due to the limited power onboard the ...
Social learning among transplant sports event volunteers

Ng, Kwok W.; Salmikangas, Anna-Katriina (European Federation of Adapted Physical Activity (EUFAPA), 2019)

Volunteering in adapted sports competitions has not been studied as much as in other competitions. Survey data from volunteers in a supportive role at the European Transplant Sport Week 2016 in Finland were analysed to ...
Towards a devolved model of management of OER? The case of the Irish Higher Education Sector

Risquez, Angelica; McAvinia, Claire; Desmond, Yvonne; Bruen, Catherine (Athabasca University Press, 2020)

This paper reports on the research findings from a national project examining the issues in creating, sharing, using, and reusing open educational resources (OER) in the context of the development of open education in ...
Spontaneous solid-state co-crystallization of caffeine and urea

MacFhionnghaile, Pól; Crowley, Clare M.; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2020)

The co-crystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry and X-ray diffraction. The caffeine-urea ...
Solid sorbents as a retrofit technology for CO2 removal from natural gas under high pressure and temperature conditions

Khraisheh, Majeda; Almomani F.; Walker, Gavin M. (2020)

The capture of CO2 under high pressure and temperature is challenging and is required in a number for industrial applications including natural gas processing. In this work, we examine the use of benchmark hybrid ultraporous ...
Transcultural nursing and traditional care in sukuma ethnic group

Agyemang, John Bright (Research Publish Journals, 2019)

The global increase in population resulting in recent multicultural societies is coupled with demand for diversity of services of which healthcare is no exception. Nursing as the core of healthcare delivery with reputable ...
Poly(3,4-Ethylenedioxythiophene) nanoparticles as building blocks for hybrid thermoelectric flexible films

Serrano-Claumarchirant, José F.; Culebras, Mario; Cantarero, Andrés; Gómez, Clara M.; Muñoz-Espí, Rafael (MDPI, 2020)

Hybrid thermoelectric flexible films based on poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles and carbon nanotubes were prepared by using layer-by-layer (LbL) assembly. The employed PEDOT nanoparticles were ...
Preparing UK tennis academy players for the junior-to-senior transition: development, implementation, and evaluation of an intervention program

Pummell, Elizabeth K.L.; Lavallee, David (Elsevier, 2019)

Objectives The current case study aimed to develop, implement and evaluate an intervention program to aid preparation for the junior-to-senior transition (JST) in sport, which provides a novel contribution to the existing ...
Ariadne: evolving test data using grammatical evolution

Anjum, Muhammad Sheraz; Ryan, Conor (Springer, 2019)

Software testing is a key component in software quality assurance; it typically involves generating test data that exercises all instructions and tested conditions in a program and, due to its complexity, can consume as ...
Plasma microRNA levels in maleand female children with cystic fibrosis

Mooney, C.; McKiernan, P.J.; Raoof, R.; Henshall, D.C.; Linnane, Barry; McNally, Paul; Glasgow, A.M.A.; Green, C.M. (Nature Research, 2020)

A gender gap exists in cystic fibrosis (CF). Here we investigate whether plasma microRNA expression profiles differ between the sexes in CF children. MicroRNA expression was quantified in paediatric CF plasma (n = 12; ...
Phase engineering with all-dielectric metasurfaces for focused-optical-vortex (FOV) beams with high cross-polarization efficiency

Ahmed, Hammad; Rahim, Arbab Abdur; Maab, Husnul; Ali, Muhammad Mahmood; Mahmood, Nasir; Naureen, Sadia (Optical Society of America, 2020)

Metasurfaces, the two-dimensional (2D) metamaterials, facilitate the implementation of abrupt phase discontinuities using an array of ultrathin and subwavelength features. These metasurfaces are considered as one of the ...
Discomfort/pain and tissue oxygenation at the lower limb during circumferential compression: application to soft exoskeleton design

Kermavnar, Tjaša; O'Sullivan, Kevin J.; de Eyto, Adam; O'Sullivan, Leonard (SAGE Publications, 2020)

Objective: To establish the relationship between circumferential compression on the lower limb during simulated ramp and staircase profile loading, and the resultant relationship with discomfort/pain and tissue oxygenation. ...
'... it would be preposterous to bring a Protestant here' : religion, provincial politics and district nurses in Ireland, 1890-1904*

Breathnach, Ciara (Institute of Historical Research, 2015)

In a country where traditional or ethno-medical practices prevailed well into the twentieth century, the interface between the wider populace and ‘modern medicine’1 was complicated by undercurrents of class, cultural ...
Medical humanities: new frontier or back to the past?

Breathnach, Ciara; Walsh, Oonagh (Humanities Serving Irish Society Consortium, 2014)

In nomenclatural terms Medical Humanities is a relatively new discipline. Originating in the United States and Australia almost simultaneously, Medical Humanities is seen by many as a means of ‘making better doctors’ by ...
Making consultation meaningful: insights from a case study of the South African mental policy consultation process

Leigh Marais, Debra; Quayle, Michael; Petersen, Inge (Public Library of Science, 2020)

Background:It is widely recognised that mental health policies should be developed in consultation with those tasked with their implementation and the users affected by them. In the South African legislative context public ...
The regulation of sequence specific NF-kB DNA binding and transcription by IKKβ phosphorylation of NF-kB p50 at serine 80

Smith, Emma L.; Somma, Domenico; Kerrigan, David; McIntyre, Zoe; Cole, John J.; Ling Liang, Kai; Kiely, Patrick A.; Keeshan, Karen; Carmody, Ruaidhrı J. (Oxford University Press, 2019)

Phosphorylation of the NF-kB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-kB, and IKKβ as ...

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