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On the bacteriostatic activity of hyaluronic acid composite films

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dc.contributor.author Zamboni, Fernanda
dc.contributor.author Okoroafor, Chinonso
dc.contributor.author Ryan, Michael P.
dc.contributor.author Pembroke, Tony J.
dc.contributor.author Stróżyk, Michał Adam
dc.contributor.author Culebras, Mario
dc.contributor.author Collins, Maurice N.
dc.date.accessioned 2021-03-24T09:15:10Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9909
dc.description peer-reviewed en_US
dc.description.abstract Biofilm-related infections and contamination of biomaterials are major problems in the clinic. These contaminations are frequently caused by Staphylococcus aureus and are a pressing issue for implantable devices, catheters, contact lenses, prostheses, and wound dressings. Strategies to decrease contamination and biofilm related infections are vital for the success of implantable biomaterials. In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects. Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications. Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented. We utilise bis-(β-isocyanatoethyl) disulphide (BIED) as the crosslinker with the gel reinforced using 0.25 wt% CNF. The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined. These new HA derivatives exhibit excellent mechanical properties and are capable of withstanding physiological stresses in vivo. Antimicrobial activity of the HA derivatives were tested against Staphylococcus aureus and the results reveal antibacterial effect. These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Carbohydrate Polymers;260, 117803
dc.relation.uri https://dx.doi.org/10.1016/j.carbpol.2021.117803
dc.rights This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers Volume 260, 15 May 2021, 117803, https://dx.doi.org/10.1016/j.carbpol.2021.117803 en_US
dc.subject hyaluronic acid en_US
dc.subject carbon nanofiber en_US
dc.subject bacteriostatic en_US
dc.subject Staphylococcus aureus en_US
dc.title On the bacteriostatic activity of hyaluronic acid composite films en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.carbpol.2021.117803
dc.contributor.sponsor IRC en_US
dc.relation.projectid GOIPG/2015/3577 en_US
dc.date.embargoEndDate 2022-02-14
dc.embargo.terms 2022-02-14 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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