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A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection

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dc.contributor.author Rashid, Farhan
dc.contributor.author Waraich, Naseem
dc.contributor.author Bhatti, Imran
dc.contributor.author Saha, Shopan
dc.contributor.author Khan, Raheela N
dc.contributor.author Ahmed, Javed
dc.contributor.author Leeder, Paul C.
dc.contributor.author Larvin, Michael
dc.contributor.author Iftikhar, Syed Y
dc.date.accessioned 2021-03-03T10:53:01Z
dc.date.available 2021-03-03T10:53:01Z
dc.date.issued 2010
dc.identifier.issn 1477-7819
dc.identifier.uri http://hdl.handle.net/10344/9836
dc.description peer-reviewed en_US
dc.description.abstract Background: Elevated pre-operative neutrophil: lymphocyte ratio (NLR) has been identified as a predictor of survival in patients with hepatocellular and colorectal cancer. The aim of this study was to examine the prognostic value of an elevated preoperative NLR following resection for oesophageal cancer. Methods: Patients who underwent resection for oesophageal carcinoma from June 1997 to September 2007 were identified from a local cancer database. Data on demographics, conventional prognostic markers, laboratory analyses including blood count results, and histopathology were collected and analysed. Results: A total of 294 patients were identified with a median age at diagnosis of 65.2 (IQR 59-72) years. The median pre-operative time of blood sample collection was three days (IQR 1-8). The median neutrophil count was 64.2 × 10-9/litre, median lymphocyte count 23.9 × 10-9/litre, whilst the NLR was 2.69 (IQR 1.95-4.02). NLR did not prove to be a significant predictor of number of involved lymph nodes (Cox regression, p = 0.754), disease recurrence (p = 0.288) or death (Cox regression, p = 0.374). Furthermore, survival time was not significantly different between patients with high (≥ 3.5) or low (< 3.5) NLR (p = 0.49). Conclusion: Preoperative NLR does not appear to offer useful predictive ability for outcome, disease-free and overall survival following oesophageal cancer resection. en_US
dc.language.iso eng en_US
dc.publisher BMC en_US
dc.relation.ispartofseries World Journal of Surgical Oncology;8 (1)
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/20053279
dc.subject oesophageal cancer en_US
dc.title A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2021-03-03T09:22:28Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1186/1477-7819-8-1
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1435051
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle World J Surg Oncol
dc.description.status peer-reviewed


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