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Outcomes of point-of-care testing for influenza in the emergency department of a tertiary referral hospital in Ireland

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Show simple item record Teoh, TeeKeat Powell, J. Kelly, J. McDonnell, C. Whelan, R. O'Connell, Nuala H. Dunne, Colum P. 2021-02-22T11:14:40Z 2021-02-22T11:14:40Z 2021
dc.description peer-reviewed en_US
dc.description.abstract Background: Seasonal influenza causes significant morbidity and mortality, and represents a recurring financial burden for community- and hospital-based treatment. Nosocomial outbreaks exacerbate the impact of influenza. Rapid diagnosis of influenza has been shown to reduce transmission. However, point-of-care testing (POCT) in emergency departments and prudent direction of patients with the virus to reduce hospital-acquired infection (HAI) have not been evaluated widely. Aim: To assess performance characteristics of the Abbott ID NOW Influenza A & B 2 system, impact on incidence of hospital-acquired influenza, and admission rate ratio for patients who have POCT compared with laboratory testing. POCT was introduced in the 2018e2019 influenza season. Data from then were compared with preceding and subsequent seasons. Methods: Records of POCT and laboratory testing for the 2017e2018, 2018e2019, and 2019e2020 influenza seasons were analysed. Sensitivity and specificity of POCT were compared pairwise with Xpert Flu A/B/RSV. Patient admission rates and time of waiting for admission were compared. Findings: Compared to laboratory assay, POCT demonstrated sensitivity of 90.6% (95% confidence interval (CI): 78.6e96.5) and specificity of 99.2% (95.2e100) for influenza A, with 51.4% and 41.9% reductions in numbers of HAIs observed in the two seasons when POCT was available, respectively. The admission rate ratio for influenza cases diagnosed by POCT compared with laboratory diagnosis was 0.72 (95% CI: 0.53e0.97; P ¼ 0.031). Conclusion: POCT for influenza appears a feasible strategy for testing of patients during peak influenza virus season, with potential to reduce HAI. The relatively rapid turnaround time may also benefit clinical management of patients presenting at emergency departments with suspected influenza. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Journal of Hospital Infection;110, 45-51
dc.subject Point-of-care testing en_US
dc.subject Emergency department en_US
dc.subject Influenza en_US
dc.title Outcomes of point-of-care testing for influenza in the emergency department of a tertiary referral hospital in Ireland en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.jhin.2021.01.004
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2994645

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