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Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors

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dc.contributor.author Yetsko, Kelsey
dc.contributor.author Farrell, Jessica A.
dc.contributor.author Blackburn, Nicholas B.
dc.contributor.author Whitmore, Liam
dc.contributor.author Stammnitz, Maximilian R.
dc.contributor.author Whilde, Jenny
dc.contributor.author Eastman, Catherine B.
dc.contributor.author Rollinson Ramia, Devon
dc.contributor.author Thomas, Rachel S.
dc.contributor.author Krstic, Aleksandar
dc.contributor.author Linser, Paul
dc.contributor.author Creer, Simon
dc.contributor.author Carvalho, Gary
dc.contributor.author Devlin, Mariana A.
dc.contributor.author Nahvi, Nina
dc.contributor.author Leandro, Ana Cristina
dc.contributor.author deMaar, Thomas W.
dc.contributor.author Burkhalter, Brooke
dc.contributor.author Murchison, Elizabeth P.
dc.contributor.author Schnitzler, Christine
dc.contributor.author Duffy, David J.
dc.date.accessioned 2021-02-16T10:56:35Z
dc.date.available 2021-02-16T10:56:35Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9786
dc.description peer-reviewed en_US
dc.description.abstract Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many longer-affected sites globally. However, we do not yet understand the precise environmental, mutational and viral events driving fibropapillomatosis tumor formation and progression. Here we perform transcriptomic and immunohistochemical profiling of five fibropapillomatosis tumor types: external new, established and postsurgical regrowth tumors, and internal lung and kidney tumors. We reveal that internal tumors are molecularly distinct from the more common external tumors. However, they have a small number of conserved potentially therapeutically targetable molecular vulnerabilities in common, such as the MAPK, Wnt, TGFβ and TNF oncogenic signaling pathways. These conserved oncogenic drivers recapitulate remarkably well the core pan-cancer drivers responsible for human cancers. Fibropapillomatosis has been considered benign, but metastatic-related transcriptional signatures are strongly activated in kidney and established external tumors. Tumors in turtles with poor outcomes (died/euthanized) have genes associated with apoptosis and immune function suppressed, with these genes providing putative predictive biomarkers. Together, these results offer an improved understanding of fibropapillomatosis tumorigenesis and provide insights into the origins, inter-tumor relationships, and therapeutic treatment for this wildlife epizootic. en_US
dc.language.iso eng en_US
dc.publisher Nature en_US
dc.relation 17-033R en_US
dc.relation.ispartofseries Communications Biology;4,152
dc.subject kidney tumors en_US
dc.subject Sea turtle populations en_US
dc.title Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1038/s42003-021-01656-7
dc.contributor.sponsor The Sea Turtle Conservancy en_US
dc.contributor.sponsor Horizon 2020 en_US
dc.contributor.sponsor ERC
dc.relation.projectid 17-033R en_US
dc.relation.projectid 663830-BU115 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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