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In vitro analysis of a physiological strain sensor formulated from a PEDOT: PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite

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dc.contributor.author Tadayyon, Ghazal
dc.contributor.author Krukiewicz, Katarzyna
dc.contributor.author Britton, James
dc.contributor.author Larranaga, Aitor
dc.contributor.author Vallejo-Giraldo, Catalina
dc.contributor.author Fernandez-Yague, Marc
dc.contributor.author Guo, Yina
dc.contributor.author Orpella-Aceret, Gemma
dc.contributor.author Li, Lu
dc.contributor.author Poudel, Anup
dc.contributor.author Biggs, Manus J.
dc.date.accessioned 2021-02-15T11:43:48Z
dc.date.available 2021-02-15T11:43:48Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net.proxy.lib.ul.ie/10344/9782
dc.description peer-reviewed en_US
dc.description.abstract Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches to detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive and biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro. Analysis of these PGSU-CNTs composites demonstrated that the incorporation of functionalized CNTs into a biodegradable elastomer resulted in enhanced mechanical strength, conductivity and tailored matrix biodegradation. PGSU-CNT composites were subsequently formulated into flexible and active pressure sensors which demonstrated optimal sensitivity to applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis a with primary neural culture confirmed that PGSU-CNT composites exhibited low cytotoxicity, and supported neuron adhesion, viability, and proliferation in vitro. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation 15TIDA2992 en_US
dc.relation.ispartofseries Materials Science and Engineering: C;121, 111857
dc.subject biodegradable polymer en_US
dc.subject strain sensor en_US
dc.subject carbon nanotubes en_US
dc.subject PEDOT en_US
dc.subject poly(glycerol sebacate urethane) en_US
dc.title In vitro analysis of a physiological strain sensor formulated from a PEDOT: PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.msec.2020.111857
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor ERDF en_US
dc.contributor.sponsor European Union (EU) en_US
dc.relation.projectid 15/TIDA/2992 en_US
dc.relation.projectid 13/RC/2073 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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