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Modulation of the powder properties of lamotrigine by crystal forms

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dc.contributor.author Kavanagh, Oisín N.
dc.contributor.author Wang, Chenguang
dc.contributor.author Walker, Gavin M.
dc.contributor.author Sun, Changquan Calvin
dc.date.accessioned 2021-02-03T09:09:49Z
dc.date.available 2021-02-03T09:09:49Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9693
dc.description peer-reviewed en_US
dc.description.abstract The mechanical properties of powders determine the ease of manufacture and ultimately the quality of the oral solid dosage forms. Although poor mechanical properties of an active pharmaceutical ingredient (API) can be mitigated by using suitable excipients in a formulation, the effectiveness of that approach is limited for high dose drugs or multidrug tablets. In this context, improving the mechanical properties of the APIs through solid form optimisation is a good strategy to address such a challenge. This work explores the powder and tableting properties of various lamotrigine (LAM) solid forms with the aim to facilitate direct compression by overcoming the poor tablet ability of LAM. The two drug-drug crystals of LAM with nicotinamide and valproic acid demonstrate superior flowability and tablet ability over LAM. The improved powder properties are rationalised by structure analysis using energy framework, scanning electron microscopy, and Heckel analysis. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;595, 120274
dc.subject Solid form optimisation en_US
dc.subject Cocrystal en_US
dc.subject Crystal engineering en_US
dc.title Modulation of the powder properties of lamotrigine by crystal forms en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.ijpharm.2021.120274
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor European Union(EU) en_US
dc.relation.projectid 12/RC/2275/2 en_US
dc.relation.projectid 12/RC/2275/2 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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