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Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response

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dc.contributor.author Panseri, Silvia
dc.contributor.author Montesi, Monica
dc.contributor.author Hautcoeur, Dominique
dc.contributor.author Dozio, Samuele M.
dc.contributor.author Chamary, Shaan
dc.contributor.author De Barra, Eamonn
dc.contributor.author Tampieri, Anna
dc.contributor.author Leriche, Anne
dc.date.accessioned 2021-02-01T10:10:39Z
dc.date.available 2021-02-01T10:10:39Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9687
dc.description peer-reviewed en_US
dc.description.abstract Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.relation.ispartofseries Journal of Materials Science: Materials in Medicine;32, 3
dc.subject Biomaterial science en_US
dc.subject cell viability en_US
dc.title Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1007/s10856-020-06486-3
dc.contributor.sponsor COST en_US
dc.relation.projectid MP1301 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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