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Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis

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dc.contributor.author Ferreira, Giovanni E
dc.contributor.author McLachlan, Andrew J
dc.contributor.author Lin, Chung-Wei Christine
dc.contributor.author Zadro, Joshua R
dc.contributor.author Abdel-Shaheed, Christina
dc.contributor.author O'Keeffe, Mary
dc.contributor.author Maher, Chris G
dc.date.accessioned 2021-01-28T09:17:49Z
dc.date.available 2021-01-28T09:17:49Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9671
dc.description peer-reviewed en_US
dc.description.abstract Objective:To investigate the efficacy and safety of antidepressants for back and osteoarthritis pain compared with placebo. Design: Systematic review and meta-analysis. Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, International Pharmaceutical Abstracts, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform from inception to 15 November and updated on 12 May 2020. Eligibility Criteria For Study Selection: Randomised controlled trials comparing the efficacy or safety, or both of any antidepressant drug with placebo (active or inert) in participants with low back or neck pain, sciatica, or hip or knee osteoarthritis. Data Extraction and Synthesis: Two independent reviewers extracted data. Pain and disability were primary outcomes. Pain and disability scores were converted to a scale of 0 (no pain or disability) to 100 (worst pain or disability). A random effects model was used to calculate weighted mean differences and 95% confidence intervals. Safety (any adverse event, serious adverse events, and proportion of participants who withdrew from trials owing to adverse events) was a secondary outcome. Risk of bias was assessed with the Cochrane Collaboration’s tool and certainty of evidence with the grading of recommendations assessment, development and evaluation (GRADE) framework. en_US
dc.language.iso eng en_US
dc.publisher BMJ Publishing en_US
dc.relation.ispartofseries BMJ Open;372, m4825
dc.subject antidepressants en_US
dc.subject Pharmaceutical Abstracts en_US
dc.title Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1136/bmj.m4825
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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