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Bioactive lipids of marine microalga chlorococcum sp. SABC 012504 with anti-inflammatory and anti-thrombotic activities

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dc.contributor.author Shiels, Katie
dc.contributor.author Tsoupras, Alexandros
dc.contributor.author Lordan, Ronan
dc.contributor.author Nasopoulou, Constantina
dc.contributor.author Zabetakis, Ioannis
dc.contributor.author Murray, Patrick
dc.contributor.author Kumar, Sushanta
dc.date.accessioned 2021-01-19T09:29:34Z
dc.date.available 2021-01-19T09:29:34Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9620
dc.description peer-reviewed en_US
dc.description.abstract Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga Chlorococcum sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All tested lipid fractions showed strong anti-platelet-activating factor (PAF) and antithrombin activities in human platelets (half maximal inhibitory concentration (IC50) values ranging ~25–200 µg of lipid) with the highest activities in glyco- and phospho-lipid fractions. The structural analysis of the bioactive lipid fraction-2 revealed the presence of specific sulfoquinovosyl diacylglycerols (SQDG) bioactive molecules and the HexCer-t36:2 (t18:1/18:1 and 18:2/18:0) cerebrosides with a phytosphingosine (4-hydrosphinganine) base, while fraction-3 contained bioactive phosphatidylcholine (PC) and phosphatidylethanolamine (PE) molecules. These novel bioactive lipids of Chlorococcum sp. with putative health benefits may indicate that marine microalgae can be a sustainable alternative source for bioactive lipids production for food supplements and nutraceutical applications. However, further studies are required towards the commercial technology pathways development and biosafety analysis for the use of the microalga. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Marine Drugs;19, 28
dc.subject marine microalga en_US
dc.subject bioactive lipid en_US
dc.subject anti-inflammatory en_US
dc.title Bioactive lipids of marine microalga chlorococcum sp. SABC 012504 with anti-inflammatory and anti-thrombotic activities en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/md19010028
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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