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Generation and physicochemical characterization of posaconazole cocrystals using gas antisolvent (GAS) and supercritical solvent (CSS) methods

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dc.contributor.author Long, Barry
dc.contributor.author Verma, Vivek
dc.contributor.author Ryan, Kevin M.
dc.contributor.author Padrela, Luis
dc.date.accessioned 2021-01-15T08:45:42Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9611
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 13/12/2022
dc.description.abstract Posaconazole (PSZ) is a BCS (biopharmaceutical classification system) Class II anti-fungal drug used to treat infections in immunocompromised patients. The work presented herein describes the generation of cocrystals of PSZ with 4-aminobenzoic acid (4AMB) using supercritical CO2 as an antisolvent in GAS (Gas Antisolvent) with acetonitrile, and as a solvent in CSS (Cocrystallization with Supercritical Solvent) methods. Cocrystals of PSZ-4AMB were obtained in a 2:3 stoichiometric ratio for the first time by GAS and CSS methods, with GAS producing higher-purity samples compared to CSS method. The work presented herein investigates the influence of critical processing variables using CO2 solvent and antisolvent crystallization methods with respect to the formation of cocrystals of PSZ-4AMB. A Design of Experiments (DoE) approach was performed to assess the outcome of PSZ-4AMB formation, impacted by processing variables such as pressure, temperature, and stirring rate using GAS and CSS methods. The resulting cocrystalline phase was identified using differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The particle morphologies and size distributions were determined using scanning electron microscopy and automated static imaging, respectively. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation 12RC2275 en_US
dc.relation.ispartofseries The Journal of Supercritical Fluids;170, 105134
dc.rights This is the author’s version of a work that was accepted for publication in The Journal of Supercritical Fluids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Journal of Supercritical Fluids, 2021, 170, 105134, https://doi.org/10.1016/j.supflu.2020.105134 en_US
dc.subject supercritical fluid en_US
dc.subject cocrystallization en_US
dc.subject particle engineering en_US
dc.subject CO2 en_US
dc.subject posaconazole en_US
dc.subject design of experiment en_US
dc.title Generation and physicochemical characterization of posaconazole cocrystals using gas antisolvent (GAS) and supercritical solvent (CSS) methods en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor EI en_US
dc.contributor.sponsor ERDF en_US
dc.contributor.sponsor European Union (EU) en_US
dc.relation.projectid 12/RC/2275 en_US
dc.relation.projectid 15/US-C2C/I3133 en_US
dc.relation.projectid CF-2017-0754 en_US
dc.date.embargoEndDate 2022-12-13
dc.embargo.terms 2022-12-13 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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