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Pharmaceutical nanoparticle isolation using CO2-assisted dynamic bed coating

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dc.contributor.author Verma, Vivek
dc.contributor.author Ryan, Kevin M.
dc.contributor.author Padrela, Luis
dc.date.accessioned 2021-01-13T09:28:45Z
dc.date.available 2021-01-13T09:28:45Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9601
dc.description peer-reviewed en_US
dc.description.abstract Poor solubility of new chemical entities (NCEs) is a major bottleneck in the pharmaceutical industry which typically leads to poor drug bioavailability and efficacy. Nanotechnologies offer an interesting route to improve the apparent solubility and dissolution rate of pharmaceutical drugs, and processes such as nano-spray drying and supercritical CO2-assisted spray drying (SASD) provide a route to engineer and produce solid drug nanoparticles. However, dried nanoparticles often show poor rheological properties (e.g. flowability, tabletability) and their isolation using these methods is typically inefficient and leads to poor collection yields. The work presented herein demonstrates a novel production and isolation method for drug nanoparticles using a ‘top spray dynamic bed coating’ process, which uses CO2 spray as the fluidizing gas. Nanoparticles of three BCS class II Active Pharmaceutical Ingredients (APIs), namely carbamazepine (CBZ), ketoprofen (KET) and risperidone (RIS), were produced and successfully coated onto micron-sized microcrystalline cellulose (MCC) particles. The size distribution of the API nanoparticles was in the range of 90–490 nm. The stable forms of CBZ (form III), KET (form I), and the metastable form of RIS (form B) were produced and coated onto MCC carrier microparticles. All the isolated solids presented optimal rheological properties along with a 2–6 fold improvement in the dissolution rate of the corresponding APIs. Hence, the ‘top spray dynamic bed coater’ developed in this work demonstrates to be an efficient approach to produce and coat API nanoparticles onto carrier particles with optimal rheological properties and improved dissolution. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;592, 120032
dc.subject chemical entities en_US
dc.subject CO2 spray en_US
dc.title Pharmaceutical nanoparticle isolation using CO2-assisted dynamic bed coating en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.ijpharm.2020.120032
dc.contributor.sponsor SFI
dc.relation.projectid 12/RC/2275_P2
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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