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Designing new antibacterial wound dressings: development of a dual layer cotton material coated with poly(vinyl alcohol)_chitosan nanofibers incorporating agrimonia eupatoria L. extract

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dc.contributor.author Mouro, Cláudia
dc.contributor.author Dunne, Colum P.
dc.contributor.author Gouvei, Isabel C.
dc.date.accessioned 2021-01-05T08:56:43Z
dc.date.available 2021-01-05T08:56:43Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/9558
dc.description peer-reviewed en_US
dc.description.abstract Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced therapeutic dressings, such as electrospun membranes containing antimicrobial agents. Among the most used antimicrobial agents, medicinal plant extracts demonstrate considerable potential for clinical use, due primarily to their efficacy allied to relatively low incidence of adverse side-effects. In this context, the present work aimed to develop a unique dual-layer composite material with enhanced antibacterial activity derived from a coating layer of Poly(vinyl alcohol) (PVA) and Chitosan (CS) containing Agrimonia eupatoria L. (AG). This novel material has properties that facilitate it being electrospun above a conventional cotton gauze bandage pre-treated with 2,2,6,6-tetramethylpiperidinyl-1-oxy free radical (TEMPO). The produced dual-layer composite material demonstrated features attractive in production of wound dressings, specifically, wettability, porosity, and swelling capacity. Moreover, antibacterial assays showed that AG-incorporated into PVA_CS’s coating layer could effectively inhibit Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth. Equally important, the cytotoxic profile of the dual-layer material in normal human dermal fibroblast (NHDF) cells demonstrated biocompatibility. In summary, these data provide initial confidence that the TEMPO-oxidized cotton/PVA_CS dressing material containing AG extract demonstrates adequate mechanical attributes for use as a wound dressing and represents a promising approach to prevention of bacterial wound contamination. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation UIDB/00195/2020 en_US
dc.relation.ispartofseries Molecules;26, 83
dc.subject cotton en_US
dc.subject nanofibers en_US
dc.subject electrospinning en_US
dc.title Designing new antibacterial wound dressings: development of a dual layer cotton material coated with poly(vinyl alcohol)_chitosan nanofibers incorporating agrimonia eupatoria L. extract en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/molecules26010083
dc.contributor.sponsor EU COST action en_US
dc.relation.projectid CA15114 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2994679


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