University of Limerick Institutional Repository

Editorial: human-nature interactions: perspectives on conceptual and methodological issues

DSpace Repository

Show simple item record

dc.contributor.author MacIntyre, Tadhg E.
dc.contributor.author Beckmann, Jürgen
dc.contributor.author Calogiuri, Giovanna
dc.contributor.author Donnell, Aoife A.
dc.contributor.author Jones, Marc
dc.contributor.author Madan, Christopher R.
dc.contributor.author Rogerson, Mike
dc.contributor.author Brick, Noel E.
dc.contributor.author Nieuwenhuijsen, Mark
dc.contributor.author Gidlow, Christopher James
dc.date.accessioned 2020-12-21T09:11:29Z
dc.date.available 2020-12-21T09:11:29Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/9542
dc.description peer-reviewed en_US
dc.description.abstract Background: Three large trials of fluoxetine for stroke recovery (FOCUS (fluoxetine or control under supervision), AFFINITY (the Assessment oF FluoxetINe In sTroke recovery) and EFFECTS (Efficacy oF Fluoxetine—a randomisEd Controlled Trial in Stroke)) have been collaboratively designed with the same basic protocol to facilitate an individual patient data analysis (IPDM). The statistical analysis plan for the three individual trials has already been reported in Trials, including a brief description of the IPDM. In this protocol, we describe in detail how we will perform the IPDM. Methods/design: Data from EFFECTS and AFFINITY will be transferred securely to the FOCUS statistician, who will perform a one-stage IPDM and a two-stage IPDM. For the one-stage IPDM, data will be combined into a single data set and the same analyses performed as described for the individual trials. For the two-stage IPDM, the results for the three individual trials will be combined using fixed effects meta-analyses. The primary and secondary outcome domains for the IPDM are the same as for individual trials. We will also perform analyses according to several subgroups including country of recruitment, ethnicity and trial. We will also explore the effects of fluoxetine on our primary and secondary outcomes in subgroups defined by combinations of characteristics. We also describe additional research questions that will be addressed using the combined data set, and published subsequently, including predictors of important post-stroke problems such as seizures, low mood and bone fractures en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Fontiers in Psychology;11, 607888
dc.subject ecosystem services en_US
dc.subject biodiversity en_US
dc.subject health en_US
dc.title Editorial: human-nature interactions: perspectives on conceptual and methodological issues en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3389/fpsyg.2020.607888
dc.contributor.sponsor European Union (EU) en_US
dc.relation.projectid 869764 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search ULIR


Browse

My Account

Statistics