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Small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study

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dc.contributor.author Ismail, Khadijah I.
dc.contributor.author Hannigan, Ailish
dc.contributor.author Kelehan, Peter
dc.contributor.author Fitzgerald, Brendan
dc.contributor.author O'Donoghue, Keelin
dc.contributor.author Cotter, Amanda
dc.date.accessioned 2020-09-25T07:53:56Z
dc.date.available 2020-09-25T07:53:56Z
dc.date.issued 2019
dc.identifier.citation Ismail K.;Hannigan A.;Kelehan P.;Fitzgerald B.;Oâ Donoghue K.;Cotter A. (2019) 'Small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study'. Journal Of Maternal-Fetal & Neonatal Medicine, . en_US
dc.identifier.issn 1476-7058
dc.identifier.uri http://hdl.handle.net/10344/9266
dc.description peer-reviewed en_US
dc.description.abstract Introduction: Individual placental and umbilical cord morphometry have been previously identified to have an association with fetal growth. This study aims to identify which of the morphometric measurements in combination are associated with pregnancies with small for gestational age (SGA) infants using digital imaging of the delivered placenta. Material and methods: This study examined 1005 placentas from consecutively delivered singleton pregnancies in a tertiary center. Standardized images of each placenta were taken. Placental weight and thickness; umbilical cord length and diameter were measured on gross examination. Distance from the placental cord insertion site to placental margin, length and breadth of the placenta and placental chorionic surface area were measured digitally using ImageJ software. Logistic regression models and area under the curve (AUC) were used to identify the best subset of morphometric measurements to classify infants as SGA (<10th centile). Results: Overall, 141 (14%) infants were SGA. The morphometric measurements at delivery most strongly associated with the classification of infants as SGA were placental weight (AUC = 0.806) and placental surface area (AUC = 0.749). Of the potential antenatal morphometric measurements, umbilical cord diameters, both placental (AUC = 0.644) and fetal end (AUC = 0.629) were most strongly associated with SGA. A logistic regression model with maternal age, smoking status, current history of preeclampsia, umbilical cord length, placental weight, birthweight-to-placental weight ratio and umbilical cord diameter (placental end) had a sensitivity of 53% and a false-positive rate of 2% (AUC = 0.945) for the classification of infants as SGA. Conclusion: Placental and umbilical cord morphometry measured at delivery are different between SGA and non-SGA infants. Further studies are warranted to investigate the feasibility and accuracy of ultrasound to measure placental and umbilical cord morphometry during pregnancy. en_US
dc.language.iso eng en_US
dc.publisher Taylor and Francis en_US
dc.relation.ispartofseries The Journal of Maternal-Fetal & Neonatal Medicine;33 (1), pp. 3632-3639
dc.relation.uri https://doi.org/10.1080/14767058.2019.1582628
dc.rights This is an Author's Accepted Manuscript of an article whose final and definitive form, the Version of Record, has been published in The Journal of Maternal-Fetal & Neonatal Medicine 2019 copyright Taylor & Francis, available online at: https://doi.org/10.1080/14767058.2019.1582628 en_US
dc.subject Birthweight en_US
dc.subject digital imaging en_US
dc.subject morphometry en_US
dc.subject placental measurements en_US
dc.subject small for gestational age en_US
dc.subject umbilical cord measurements en_US
dc.title Small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2020-09-25T07:25:48Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1080/14767058.2019.1582628
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2900239
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Journal Of Maternal-Fetal & Neonatal Medicine
dc.description.status peer-reviewed


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