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Mild cognitive impairment and sedentary behavior: a multinational study.

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dc.contributor.author Vancampfort, Davy
dc.contributor.author Stubbs, Brendon
dc.contributor.author Lara, Elvira
dc.contributor.author Vandenbulcke, Mathieu
dc.contributor.author Swinnen, Nathalie
dc.contributor.author Smith, Lee
dc.contributor.author Firth, Joseph
dc.contributor.author Herring, Matthew P.
dc.contributor.author Hallgren, Mats
dc.contributor.author Koyanagi, Ai
dc.date.accessioned 2020-07-31T10:26:39Z
dc.date.available 2020-07-31T10:26:39Z
dc.date.issued 2018
dc.identifier.citation Vancampfort D;Stubbs B;Lara E;Vandenbulcke M;Swinnen N;Smith L;Firth J;Herring MP;Hallgren M;Koyanagi A; (2018) 'Mild cognitive impairment and sedentary behavior: A multinational study'. Experimental Gerontology, 108 . en_US
dc.identifier.issn 1873-6815
dc.identifier.uri http://hdl.handle.net/10344/9066
dc.description peer-reviewed en_US
dc.description.abstract Background Sedentary behavior (SB) is associated with poor cognitive performance. However, the contribution of sedentary time to risk of mild cognitive impairment (MCI) remains unclear. This study assessed the association of SB with MCI in six low- and middle-income countries. Methods The Study on Global Ageing and Adult Health (SAGE) survey included 34,129 adults aged ≥50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. SB was self-reported and expressed as a categorical variable [<8 or ≥8 h per day (high SB)]. The definition of MCI was based on the recommendations of the National Institute on Ageing-Alzheimer's Association. Multivariable logistic regression analysis was conducted to assess the association between SB and MCI. Results The overall prevalence (95%CI) of MCI and high SB (i.e., ≥8 h/day) were 15.3% (14.4%–16.3%) and 10.1% (9.0%–11.3%), respectively. After adjustment for potential confounders, being sedentary for ≥8 h/day was associated with a 1.56 (95%CI = 1.27–1.91) times higher odds for MCI. A one-hour increase in SB was associated with a 1.08 (95%CI = 1.05–1.11) times higher odds for MCI. Conclusion Our study results highlight the need to further explore a sedentary lifestyle as a potential risk factor for MCI or subsequent dementia. Longitudinal and intervention studies are warranted to confirm/refute the current findings. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Experimental Gerontology;108, pp.174-180
dc.relation.uri https://doi.org/10.1016/j.exger.2018.04.017
dc.rights This is the author’s version of a work that was accepted for publication in Experimental Gerontology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Experimental Gerontology, 2018, 108, pp. 174-180, https://doi.org/10.1016/j.exger.2018.04.017 en_US
dc.subject mild cognitive impairment en_US
dc.subject dementia en_US
dc.subject sedentary Sitting en_US
dc.title Mild cognitive impairment and sedentary behavior: a multinational study. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2020-07-31T10:11:05Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1016/j.exger.2018.04.017
dc.contributor.sponsor National Institute for Health Research (NIHR) en_US
dc.relation.projectid CP13/00150 en_US
dc.relation.projectid PI15/00862 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2863115
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Experimental Gerontology
dc.description.status peer-reviewed


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