dc.contributor.author |
McLaughlin, Chris M. |
|
dc.contributor.author |
Sharkey, Shaun J. |
|
dc.contributor.author |
Harnedy-Rothwell, Pádraigín A. |
|
dc.contributor.author |
Parthsarathy, Vadivel |
|
dc.contributor.author |
Allsopp, Philip J. |
|
dc.contributor.author |
McSorley, Emeir M. |
|
dc.contributor.author |
Fitzgerald, Richard J. |
|
dc.contributor.author |
O'Harte, Finbarr P.M. |
|
dc.date.accessioned |
2020-07-24T10:24:26Z |
|
dc.date.available |
2020-07-24T10:24:26Z |
|
dc.date.issued |
2020 |
|
dc.identifier.uri |
http://hdl.handle.net/10344/9037 |
|
dc.description |
peer-reviewed |
en_US |
dc.description.abstract |
This study investigated the antihyperglycaemic effectiveness of an oral Palmaria palmata protein hydrolysate (PPPH), versus metformin, upon metabolic control in streptozotocin (STZ)-induced diabetic mice. Mice were administered PPPH (50 mg/kg bodyweight) or metformin (200 mg/kg bodyweight) by oral gavage twice-daily for 18 days. Blood glucose and plasma insulin were measured every third day. PPPH caused a significant reduction
in blood glucose (p < 0.001) and a significant increase in plasma insulin (p < 0.001) versus STZtreated saline controls. PPPH treatment reduced energy intake (p < 0.05), bodyweight (p < 0.01) and total plasma glucagon-like peptide-1 (p < 0.01) after 18 days. Terminal oral glucose tolerance (Day 18, p < 0.05), fasting blood glucose (p < 0.001), HbA1C (p < 0.01), plasma cholesterol (p < 0.01) and plasma triglycerides (p < 0.05) were significantly improved versus STZ-treated saline controls. All groups showed significant increases in pancreatic islet area, β-cell area, and β:α cell ratio. PPPH demonstrated potent antidiabetic potential in vivo through reduced food intake and improved beta-cell function. |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.relation.ispartofseries |
Journal of Functional Foods;73, 104101 |
|
dc.subject |
Streptozotocin induced diabetes |
en_US |
dc.subject |
Insulin secretion |
en_US |
dc.subject |
Palmaria palmata |
en_US |
dc.subject |
Protein hydrolysate |
en_US |
dc.title |
Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles |
en_US |
dc.type |
info:eu-repo/semantics/article |
en_US |
dc.type.supercollection |
all_ul_research |
en_US |
dc.type.supercollection |
ul_published_reviewed |
en_US |
dc.identifier.doi |
10.1016/j.jff.2020.104101 |
|
dc.contributor.sponsor |
Department of Agriculture, Food and the Marine |
en_US |
dc.contributor.sponsor |
Northern Ireland Department for Employment and Learning |
en_US |
dc.relation.projectid |
13/F/467 |
en_US |
dc.rights.accessrights |
info:eu-repo/semantics/openAccess |
en_US |