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Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

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dc.contributor.author McLaughlin, Christopher M.
dc.contributor.author Sharkey, Shaun J
dc.contributor.author Harnedy-Rothwell, Pádraigín A.
dc.contributor.author Parthsarathy, Vadivel
dc.contributor.author Allsopp, Philip J.
dc.contributor.author McSorley, Emeir M.
dc.contributor.author Fitzgerald, Richard J.
dc.contributor.author O'Harte, Finbarr P.M.
dc.date.accessioned 2020-07-24T10:24:26Z
dc.date.available 2020-07-24T10:24:26Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/9037
dc.description peer-reviewed en_US
dc.description.abstract This study investigated the antihyperglycaemic effectiveness of an oral Palmaria palmata protein hydrolysate (PPPH), versus metformin, upon metabolic control in streptozotocin (STZ)-induced diabetic mice. Mice were administered PPPH (50 mg/kg bodyweight) or metformin (200 mg/kg bodyweight) by oral gavage twice-daily for 18 days. Blood glucose and plasma insulin were measured every third day. PPPH caused a significant reduction in blood glucose (p < 0.001) and a significant increase in plasma insulin (p < 0.001) versus STZtreated saline controls. PPPH treatment reduced energy intake (p < 0.05), bodyweight (p < 0.01) and total plasma glucagon-like peptide-1 (p < 0.01) after 18 days. Terminal oral glucose tolerance (Day 18, p < 0.05), fasting blood glucose (p < 0.001), HbA1C (p < 0.01), plasma cholesterol (p < 0.01) and plasma triglycerides (p < 0.05) were significantly improved versus STZ-treated saline controls. All groups showed significant increases in pancreatic islet area, β-cell area, and β:α cell ratio. PPPH demonstrated potent antidiabetic potential in vivo through reduced food intake and improved beta-cell function. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Journal of Functional Foods;73, 104101
dc.subject Streptozotocin induced diabetes en_US
dc.subject Insulin secretion en_US
dc.subject Palmaria palmata en_US
dc.subject Protein hydrolysate en_US
dc.title Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.jff.2020.104101
dc.contributor.sponsor Dep. of Agriculture, Food and the Marine Ireland en_US
dc.contributor.sponsor Northern Ireland Department for Employment & Learning en_US
dc.relation.projectid 13/F/467 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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