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Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution

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dc.contributor.author Macchi, Edoardo Gino
dc.contributor.author Tosi, Daniele
dc.contributor.author Braschi, Giovanni
dc.contributor.author Gallati, Mario
dc.contributor.author Cigada, Alfredo
dc.contributor.author Busca, Giorgio
dc.contributor.author Lewis, Elfed
dc.date.accessioned 2020-07-22T11:49:56Z
dc.date.available 2020-07-22T11:49:56Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/9026
dc.description peer-reviewed en_US
dc.description.abstract Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6 degrees C/mm) and temporal (up to 1 degrees C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1 sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) en_US
dc.language.iso eng en_US
dc.publisher SPIE: The International Society for Optics and Photonics en_US
dc.relation.ispartofseries Journal of Biomedical Optics;19 (11), 117004
dc.relation.uri https://doi.org/10.1117/1.JBO.19.11.117004
dc.rights Copyright 2014 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited en_US
dc.subject fiber optic sensors en_US
dc.subject distributed temperature sensor en_US
dc.subject radiofrequency thermal ablation en_US
dc.subject ex vivo liver tissue en_US
dc.subject Rayleigh backscattering en_US
dc.title Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2020-07-22T11:40:17Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1117/1.JBO.19.11.117004
dc.contributor.sponsor Marie Curie Actions en_US
dc.relation.projectid MC-IEF-299985 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1578451
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Journal Of Biomedical Optics
dc.description.status peer-reviewed


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