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Concentrations of essential trace metals in the brain of animal species—A comparative study

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Show simple item record De Benedictis, Chiara A. Raab, Andrea Ducie, Ellen Howley, Shauna Feldmann, Joerg Grabrucker, Andreas M. 2020-07-21T09:05:26Z 2020-07-21T09:05:26Z 2020
dc.description peer-reviewed en_US
dc.description.abstract The essential trace metals iron, zinc, and copper have a significant physiological role in healthy brain development and function. Especially zinc is important for neurogenesis, synaptogenesis, synaptic transmission and plasticity, and neurite outgrowth. Given the key role of trace metals in many cellular processes, it is important to maintain adequate levels in the brain. However, the physiological concentration of trace metals, and in particular zinc, in the human and animal brain is not well described so far. For example, little is known about the trace metal content of the brain of animals outside the class of mammals. Here, we report the concentration of iron, zinc, and copper in fresh brain tissue of different model-species of the phyla Chordata (vertebrates (mammals, fish)), Annelida, Arthropoda (insects), and Mollusca (snails), using inductively coupled plasma mass-spectrometry (ICP-MS). Our results show that the trace metals are present in the nervous system of all species and that significant differences can be detected between species of different phyla. We further show that a region-specific distribution of metals within the nervous system already exists in earthworms, hinting at a tightly controlled metal distribution. In line with this, the trace metal content of the brain of different species does not simply correlate with brain size. We conclude that although the functional consequences of the controlled metal homeostasis within the brain of many species remains elusive, trace metal biology may not only play an important role in the nervous system of mammals but across the whole animal kingdom en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Brain Sciences;10, 460
dc.subject zinc en_US
dc.subject iron en_US
dc.subject copper en_US
dc.subject selenium en_US
dc.title Concentrations of essential trace metals in the brain of animal species—A comparative study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/brainsci10070460
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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