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Now showing items 2759-2778 of 3746

RAB40C regulates RACK1 stability via theubiquitin–proteasome system

Day, John P.; Whiteley, Ellanor; Freeley, Michael; Long, Aideen; Malacrida, Beatrice; Kiely, Patrick A.; Baillie, George S. (Future Science, 2018)

Aim: RACK1 is a multifunctional scaffolding protein that is expressed in many cellular compartments, orchestrating a number of signaling processes. RACK1 acts as a signaling hub to localize active enzymes to discrete ...
Racemic amino acid piezoelectric transducer

Guerin, Sarah; O'Donnell, Joseph; Haq, Ehtsham U.; McKeown, Cian; Silien, Christophe; Rhen, Fernando M.F.; Soulimane, Tewfik; Tofail, Syed A.M.; Thompson, Damien (American Physical Society, 2019)

Single crystal L-amino acids can exhibit technologically useful piezoelectric and nonlinear optical properties. Here we predict, using density functional theory, the piezoelectric charge and strain and voltage tensors of ...
RACK(1) to the future - a historical perspective

Ron, Dorit; Adams, David R.; Baillie, George S.; Long, Aideen; O'Connor, Rosemary; Kiely, Patrick A. (BioMed Central, 2013)

This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1's role in the immune system, the heart and the brain were discussed and its ...
RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells

Kiely, Maeve (University of Limerick, 2014)

Breast cancer is a leading cause of cancer death worldwide but targeted therapies have proven to be very successful in the treatment of this disease. The aim of this study was to develop models and parameters that will ...
RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

Kiely, Maeve; Adams, David R.; Hayes, Sheri L.; O'Connor, Rosemary; Baillie, George S.; Kiely, Patrick A. (Elsevier, 2017)

Conflicting reports implicate the scaffolding protein RACK1 in the progression of breast cancer. RACK1 has been identified as a key regulator downstream of growth factor and adhesion signalling and as a direct binding ...
RACK1, a multifaceted scaffolding protein: structure and function.

Adams, David R.; Ron, Dorit; Kiely, Patrick A. (BioMed Central, 2011)

The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the Î² subunit of G-proteins (GÎ²). RACK1 adopts a seven-bladed ...
Radiation-induced changes in the electrical properties of TiO2 thick films

Arshak, Khalil; Korostynska, Olga; Arshak, Arousian; Morris, Deirdre (IEEE Computer Society, 2005)

The electrical properties of screen-printed TiO2 based thick films were explored in terms of gamma radiation influence. Screen-printed pn-heterojunctions and resistors were exposed to γ- radiation from a 137Cs source ...
Radical love: architecture and the efficacy of the new

Mullen, Benjamin (School of Architecture, University of Limerick, 2013)

I would like to offer a brief introduction to this thesis document. The work that follows takes as its staring point the universal theme of love as it could (or should) relate to architecture, historically and presently. ...
Radiotherapy dosimetry based on perflourinated polymer opitcal fibres

Olusoji, Olugbenga. J.; Kam, Wern; O'Keeffe, Sinéad (SPIE: The International Society for Optics and Phontonics, 2020)

The complexity of treating cancerous cells in patients using radiotherapy, requires precision in terms of the total dose received by the patient. The use of scintillating materials at the tip of the fibre for real time ...
Rail-to-rail op-amp design incorporating negative miller and miller compensation

Zaidi, Muhaned Ali Hussein; Grout, Ian; A'ain, Abu Khari (I.J.S.E.I, 2018)

This paper considers and presents the design of a rail-to-rail input and output CMOS (complementary metal oxide semiconductor) two-stage operational amplifier (op-amp). The design uses two capacitance based compensation ...
Raman spectroscopy of fingernails: a novel tool for evaluation of bone quality?

Cummins, Niamh M.; Day, J.C.C.; Wren, A.W.; Carroll, P.; Murphy, N.; Jakeman, Philip M.; Towler, M.R. (Hindawi Publishing Corporation, 2010)

Raman data from human fingernails has been analysed to determine if a relationship exists between spectral features and bone quality. Previous work demonstrated a relationship between the manually determined intensity of ...
Random depth access full-field heterodyne low-coherence interferometry utilizing acousto-optic modulation and a complementary metal-oxide semiconductor camera

Egan, Patrick; Connelly, Michael J.; Lakestani, Fereydoun; Whelan, Maurice P. (Optical Society of America, 2006)

With analog scanning, time-domain low-coherence interferometry lacks precise depth information, and optical carrier generation demands a linear scanning speed. Full-field heterodyne low-coherence interferometry that uses ...
Ranking the effects of cycle time parameters, shoulder posture and load, on shoulder discomfort in a single experiment using Taguchi methods

Browne, Aleksandra; O'Sullivan, Leonard (Cogent OA, 2017)

The purpose of this study was to use the Taguchi Design of Experiments approach to investigate the effects of five risk factors on ratings of shoulder discomfort in a single study. The development of shoulder MusculoSkeletal ...
Rapid GUI development on legacy systems: a runtime model-based solution

Song, Hui; Gallagher, Michael; Clarke, Siobhán (Association for Computing Machinery, 2012)

Graphical User Interface (GUI) is a common feature for modern software systems, while there are still many legacy systems that do not have GUIs, but only provide text and commands for user interaction. In this paper, ...
Rapid microwave assisted synthesis and characterisation of a semiconducting polymer with pKa tuneable degradation properties

Heffernan, Maria M.; O'Reilly, Emmet J. (Elsevier, 2019)

As part of ongoing efforts to develop electroactive polymers (EAPs) which are biodegradable/bioresorbable, we report on the microwave assisted synthesis and characterization of an electrically conducting and electroactive ...
Rapid synthesis and decoration of reduced graphene oxide with gold nanoparticles by thermostable peptides for memory device and photothermal applications

Otari, Sachin V; Kumar, Manoj; Anwar, Muhammad Zahid; Thorat, Nanasaheb D.; Patel, Sanjay K.S; Lee, Dongjin; Lee, Jai Hyo; Lee, Jung-Kul; Kang, Yun Chan; Zhang, Liaoyuan (Nature Publishing Group, 2017)

This article presents novel, rapid, and environmentally benign synthesis method for one-step reduction and decoration of graphene oxide with gold nanoparticles (NAuNPs) by using thermostable antimicrobial nisin peptides ...
Rationale, implementation and evaluation of assistive strategies for an active back-support exoskeleton

Toxiri, Stefano; Koopman, Axel S.; Lazzaroni, Maria; Ortiz, Jesús; Power, Valerie; de Looze, Michiel P.; O'Sullivan, Leonard; Caldwell, Darwin G. (Frontiers Media, 2018)

Active exoskeletons are potentially more effective and versatile than passive ones, but designing them poses a number of additional challenges. An important open challenge in the field is associated to the assistive ...
Rationalising crystal nucleation of organic molecules in solution using artificial neural networks

Hjorth, Timothy; Svärd, Michael; Rasmuson, Åke C. (Royal Society of Chemistry, 2019)

In this study, the method of artificial neural networks (ANNs) is applied to analyse the effect of various solute, solvent, and solution properties on the difficulty of primary nucleation, without bias towards any ...
Rayleigh-Bénard convection at high Rayleigh number and infinite Prandtl number: asymptotics and numerics

Vynnycky, Michael; Masuda, Y (American Institute of Physics, 2013)

The problem of fast viscous steady Rayleigh-Bénard convection in a rectangular enclosure is revisited using asymptotic and numerical methods. There are two generic cases: in the first, there is zero shear stress at all ...
RE challenges for geographically distributed stakeholders

Caulfield, Irene; Power, Norah (2008)

This paper describes preliminary results of a longitudinal case study of an Irish based automotive aftermarket company engaged in software development with multiple stakeholders that are geographically separated. Due to ...

Now showing items 2759-2778 of 3746

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