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Personalised mapping of tumour development in synchronous colorectal cancer patients

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Show simple item record Thomas, Valentina Cotter, Maura B. Tosetto, Miriam Khaw, Yi Ling Geraghty, Robert Winter, Desmond C Ryan, Elizabeth J. Sheahan, Kieran Furney, Simon J. 2020-07-08T08:25:25Z 2020-07-08T08:25:25Z 2020
dc.description peer-reviewed en_US
dc.description.abstract Synchronous colorectal cancers (syCRCs) are two or more primary tumours identified simultaneously in a patient. Previous studies report high inter-tumour heterogeneity between syCRCs, suggesting independent origin and different treatment response, making their management particularly challenging, with no specific guidelines currently in place. Here, we performed in-depth bioinformatic analyses of genomic and transcriptomic data of a total of eleven syCRCs and one metachronous CRC collected from three patients. We found mixed microsatellite status between and within patients. Overlap of mutations between synchronous tumours was consistently low (<0.5%) and heterogeneity of driver events across syCRCs was high in all patients. Microbial analysis revealed the presence of Fusobacterium nucleatum species in patients with MSI tumours, while quantification of tumour immune infiltration showed varying immune responses between syCRCs. Our results suggest high heterogeneity of syCRCs within patients but find clinically actionable biomarkers that help predict responses to currently available targeted therapies. Our study highlights the importance of personalised genome and transcriptome sequencing of all synchronous lesions to aid therapy decision and improve management of syCRC patients. en_US
dc.language.iso eng en_US
dc.publisher Nature Research en_US
dc.relation.ispartofseries npj Genomic Medicine;5,27
dc.subject genome en_US
dc.subject Fusobacterium en_US
dc.title Personalised mapping of tumour development in synchronous colorectal cancer patients en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1038/s41525-020-0134-3
dc.contributor.sponsor St. Vincent’s Foundation Cancer Fund en_US
dc.contributor.sponsor Ireland Health Foundation en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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