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Surgical treatment of intestinal stricture in inflammatory bowel disease

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Show simple item record Mohan, Helen M. Coffey, Calvin J. 2020-07-03T11:45:24Z 2020
dc.description peer-reviewed en_US
dc.description.abstract Fibroblast infiltration and collagen deposition result in structural changes in the bowel wall, and lead to strictures in intestinal inflammatory disease. While strictures can also occur in other contexts, such as malignancy, this review focuses on the surgical treatment of stricture secondary to inflammatory bowel disease. Distinguishing between predominantly inflammation vs established fibrosis as the cause of a stricture can be challenging. While inflammatory strictures may be responsive to medication, predominantly fibrotic strictures usually need surgical intervention. Both endoluminal and extraluminal approaches are described in this review. Endoscopic dilatation of strictures is suitable for short‐segment isolated small bowel strictures. Other options are to divide the stricture surgically but preserve the length, performing a strictureplasty or resecting the strictured segment. The mesentery is increasingly recognized as playing a role in stricture recurrence. In a relapsing‐remitting disease such as Crohn's disease, the preservation of intestinal length is essential and balance is needed between this and a complete resection to reduce the risk of recurrence. Pre‐ and postoperative involvement of the multidisciplinary team is essential to improve outcomes in this challenging clinical scenario. en_US
dc.language.iso eng en_US
dc.publisher Wiley and Sons Ltd en_US
dc.relation.ispartofseries Journal of Digestive Diseases; 21 (6), pp. 355-359
dc.rights This is the peer reviewed author version of the following article:Surgical treatment of intestinal stricture in inflammatory bowel disease , which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en_US
dc.subject Crohn disease en_US
dc.subject inflammatory bowel diseases en_US
dc.subject mesentery en_US
dc.subject resection en_US
dc.subject stricture en_US
dc.subject strictureplasty en_US
dc.title Surgical treatment of intestinal stricture in inflammatory bowel disease en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1111/1751-2980.12880 2021-05-14
dc.embargo.terms 2021-05-14 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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