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Enzymatic biofuel cells for self-powered, controlled drug release.

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dc.contributor.author Xiao, Xinxin
dc.contributor.author McGourty, Kieran Denis
dc.contributor.author Magner, Edmond
dc.date.accessioned 2020-06-24T08:11:15Z
dc.date.issued 2020
dc.identifier.citation Xiao X;Denis McGourty K;Magner E; (2020) 'Enzymatic Biofuel Cells for Self-Powered, Controlled Drug Release'. Journal of the American Chemical Society, . en_US
dc.identifier.issn 1520-5126
dc.identifier.uri http://hdl.handle.net/10344/8948
dc.description peer-reviewed en_US
dc.description.abstract Self-powered drug delivery systems based on conductive polymers (CPs) that eliminate the need for external power sources, are of significant interest for use in clinical applications. Osmium redox polymer mediated glucose/O2 enzymatic biofuel cells (EBFCs) were prepared with an addi-tional CP-drug layer on the cathode. On discharging the EBFCs in the presence of glucose and dioxygen, model drug compounds incorporated in the CP layer were rapidly released with negligible amounts released when the EBFCs were held at open circuit. Controlled and ex situ release of three model compounds, ibuprofen (IBU), fluorescein (FLU) and 4',6-diamidino-2-phenylindole (DAPI), was achieved with this self-powered drug release system. DAPI released in situ in cell culture media was incorporated into retinal pigment epithelium (RPE) cells. This work demonstrates a proof-of-concept responsive drug release system that may be used in implantable devices. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 607793 en_US
dc.relation.ispartofseries Journal of the American Chemical Society;142 (26), pp. 11602-11609
dc.rights © 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.0c05749 en_US
dc.subject drug delivery systems en_US
dc.title Enzymatic biofuel cells for self-powered, controlled drug release. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2020-06-23T13:43:55Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1021/jacs.0c05749
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor IRC en_US
dc.contributor.sponsor European Union (EU)
dc.relation.projectid 607793 en_US
dc.relation.projectid GOIPG/2014/659 en_US
dc.date.embargoEndDate 2021-06-08
dc.embargo.terms 2021-06-08 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2958327
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Journal of the American Chemical Society:
dc.description.status peer-reviewed


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