University of Limerick Institutional Repository

Labile crosslinked hyaluronic acid via urethane formation using bis(β- isocyanatoethyl) disulphide with tuneable physicochemical and immunomodulatory properties

DSpace Repository

Show simple item record

dc.contributor.author Zamboni, Fernanda
dc.contributor.author Ryan, Elizabeth J.
dc.contributor.author Culebras, Mario
dc.contributor.author Collins, Maurice N.
dc.date.accessioned 2020-06-22T08:53:05Z
dc.date.available 2020-06-22T08:53:05Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8943
dc.description peer-reviewed en_US
dc.description.abstract Here, we synthesise a new isocyanate-based crosslinker with the aim of obtaining novel tailored gels. The newly crosslinked hyaluronic acid (HA) gels were analysed in terms of rheological properties, chemical structure, swelling, biocompatibility and immunological response. Results show that the synthesised di-isocyanate outperforms other more conventional di-isocyanates due to its alkyl-based which has been shown to be slower to degrade by hydrolysis than aryl isocyanates. The alkyl-based isocyanate reacts readily with hydroxyl groups on the HA to form stable carbamate crosslinkages. Importantly and uniquely, a centrally located disulphide bond allows versatility with respect to reversible crosslinking and this allows potentially controlled layer-by-layer deposition of the HA for tailored pharmaceutical applications. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation GOIPG en_US
dc.relation.ispartofseries Carbohydrate Polymers;245, 116501
dc.subject Hyaluronic acid en_US
dc.subject Diisocyanate en_US
dc.subject Crosslinking en_US
dc.subject Biocompatibility en_US
dc.title Labile crosslinked hyaluronic acid via urethane formation using bis(β- isocyanatoethyl) disulphide with tuneable physicochemical and immunomodulatory properties en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.carbpol.2020.116501
dc.contributor.sponsor IRC en_US
dc.relation.projectid GOIPG/ 2015/3577 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search ULIR


Browse

My Account

Statistics