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Drug loading and dissolution properties of dalcetrapib–montmorillonite nanocomposite microparticles

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dc.contributor.author Bodnár, Katalin
dc.contributor.author Hudson, Sarah P.
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2020-05-05T13:18:02Z
dc.date.available 2020-05-05T13:18:02Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8787
dc.description peer-reviewed en_US
dc.description.abstract This work aims to transfer the fast dissolution performances of drug nanosuspensions into the solid state via a carrier particle-mediated isolation method and explores the factors affecting the maximum achievable drug loading of the prepared nanocomposite microparticles. The solid composites of fast dissolving dalcetrapib (DCP) nanoparticles on larger montmorillonite (MMT) carrier microparticles have been prepared by an antisolvent precipitation method. The very high dissolution rate of the DCP nanoparticles is combined with the simple solid–liquid separation and drying of the MMT composite microparticles. The fast dissolution rate of DCP from the solid-state nanocomposite microparticles was maintained up to a drug loading of 20.9%, and the formulation was stable for a minimum of 10 weeks in the solid state. Surface functionalization of the MMT particles was not needed for a high and uniform attachment of nanoparticles. Addition of soluble surfactant and polymeric additives, generally used for stabilization of nanosuspensions, was not required and even decreased the DCP nanoparticle attachment and thus limited drug loading en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 12RC2275 en_US
dc.relation.ispartofseries Organic Process Research & Development; 24 (6), pp. 977-987
dc.relation.uri http://dx.doi.org/10.1021/acs.oprd.9b00460
dc.rights © 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research and Development , copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work seehttp://dx.doi.org/10.1021/acs.oprd.9b00460 en_US
dc.subject drug nanoparticles en_US
dc.subject carrier particles en_US
dc.subject antisolvent precipitation en_US
dc.subject dissolution rate en_US
dc.subject poorly soluble drug en_US
dc.subject isolation en_US
dc.title Drug loading and dissolution properties of dalcetrapib–montmorillonite nanocomposite microparticles en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acs.oprd.9b00460
dc.contributor.sponsor SFI en_US
dc.relation.projectid 2021-04-14 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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