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Organic salts of pharmaceutical impurity ρ-Aminophenol

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Show simple item record Khandavilli, U. B. Rao Keshavarz, Leila Skořepová, Eliška Steendam, René R.E. Frawley, Patrick J. 2020-05-05T10:40:08Z 2020-05-05T10:40:08Z 2020
dc.description peer-reviewed en_US
dc.description.abstract The presence of impurities can drastically affect the efficacy and safety of pharmaceutical entities. ρ-Aminophenol (PAP) is one of the main impurities of paracetamol (PA) that can potentially show toxic effects such as maternal toxicity and nephrotoxicity. The removal of PAP from PA is challenging and diffi cult to achieve through regular crystallization approaches. In this regard, we report four new salts of PAP with salicylic acid (SA), oxalic acid (OX), l-tartaric acid (TA), and (1S)-(+)-10-camphorsulfonic acid (CSA). All the PAP salts were analyzed using single-crystal X-ray diffraction, powder X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. The presence of minute amounts of PAP in paracetamol solids gives a dark color to the product that was diffi cult to remove through crystallization. In our study, we found that the addition of small quantities of the aforementioned acids helps to remove PAP from PA during the filtration and washings. This shows that salt formation could be used to efficiently remove challenging impurities. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation TJ02000256 en_US
dc.relation.ispartofseries Molecules;25, 1910
dc.subject paracetamol en_US
dc.subject 4-aminophenol en_US
dc.subject impurity removal en_US
dc.subject salt en_US
dc.title Organic salts of pharmaceutical impurity ρ-Aminophenol en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/molecules25081910
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor Czech Science Foundation en_US
dc.contributor.sponsor Czech Republic en_US
dc.relation.projectid 12/RC/2275 en_US
dc.relation.projectid 17-23196S en_US
dc.relation.projectid TJ02000256 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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