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MRI guided magneto-chemotherapy with high-magnetic-moment iron oxide nanoparticles for cancer theranostics

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dc.contributor.author Salunkhe, Ashwini
dc.contributor.author Khot, Vishwajeet
dc.contributor.author Patil, S. I.
dc.contributor.author Tofail, Syed A.M.
dc.contributor.author Bauer, Joanna
dc.contributor.author Thorat, Nanasaheb D.
dc.date.accessioned 2020-04-30T10:50:01Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8776
dc.description peer-reviewed en_US
dc.description.abstract Elevating and monitoring the temperature of tumors using magnetic nanoparticles (MNPs) still presents a challenge in magnetic hyperthermia therapy. The efficient heating of tumor volume can be achieved by preparing MNPs with high magnetization values. The next-generation approach to magnetic resonance image (MRI)-guided magneto-chemotherapy of cancer based on high-magnetic-moment iron oxide nanoparticles is proposed. The proof of concept is validated by cellular MRI experiments on breast cancer cells. To explore magneto-chemotherapy, we developed high-magnetic-moment iron oxide (Fe3O4) nanoparticles (NPs) using base diisopropylamine (DIPA), which plays a dual role as reducing agent and surface stabilizer. Spherical NPs with ∼12 nm size and a high magnetization value of about 92 emu g–1 at room temperature are obtained by this unique method. A high specific absorption rate value of ∼717 wg–1 was obtained for Fe3O4 NPs in water at an alternating magnetic field of 20 kAm–1 and frequency of 267 kHz, which is attributed to the high magnetization value. The magneto-polymeric micelle structure is formed by using Pluronic F127, and anticancer drug doxorubicin is conjugated in the micelle by electrostatic interactions for magneto-chemotherapy. Finally, the magnetic resonance imaging (MRI)-guided magneto-chemotherapy was achieved on breast cancer (MCF7) cells with an overall ∼96% killing of cancer cells attained in 30 min of magneto-chmeotherapy. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 751903 en_US
dc.relation.ispartofseries ACS Applied Bio Materials;3 (4), pp. 2305-2313
dc.relation.uri https://doi.org/10.1021/acsabm.0c00077
dc.rights © 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials , copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.0c00077 en_US
dc.subject iron oxide nanoparticles en_US
dc.subject magnetic properties en_US
dc.subject induction heating properties en_US
dc.subject specific absorption en_US
dc.subject rate nanofluids en_US
dc.title MRI guided magneto-chemotherapy with high-magnetic-moment iron oxide nanoparticles for cancer theranostics en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acsabm.0c00077
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor IRC en_US
dc.relation.projectid GOIPD/2015/320 en_US
dc.relation.projectid 751903 en_US
dc.date.embargoEndDate 20201-03-20
dc.embargo.terms 20201-03-20 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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