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Fabricating covalent organic framework capsules with commodious microenvironment for enzymes

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dc.contributor.author Li, Mingmin
dc.contributor.author Qiao, Shan
dc.contributor.author Zheng, Yunlong
dc.contributor.author Andaloussi, Yassin H.
dc.contributor.author Li, Xia
dc.contributor.author Zhang, Zhenjie
dc.contributor.author Li, Ang
dc.contributor.author Cheng, Peng
dc.contributor.author Ma, Shengqian
dc.contributor.author Chen, Yao
dc.date.accessioned 2020-04-24T12:58:59Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8760
dc.description peer-reviewed en_US
dc.description.abstract enzyme activity is still of formidable challenge. Herein, we created a sacrificial templating method, using metal-organic frameworks (MOFs) as sacrificial templates to construct hollow covalent organic framework (COF) capsules for enzyme encapsulation. This strategy can provide capacious microenvironment to unleash enzyme molecules. The improved conformational freedom of enzymes, enhanced mass transfer and protective effect against external environment ultimately boosted the enzymatic activities. We also found that this strategy possesses high versatility that is suitable for diverse biomacromolecules, MOF templates and COF capsules. Moreover, the dimensions, pore sizes and shell thickness of COF capsules can be conveniently tuned, allowing for customizing bioreactors for specific functions. For example, coencapsulation of different enzymes with synergistic functions were successfully demonstrated using this bioreactor platform. This study not only opens up a new avenue to overcome the present limitations of enzymatic immobilization in porous matrixes but also provides new opportunities for construction of biomicrodevices or artificial organelles based on crystalline porous materials. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries Journal of the American Chemical Society;142 (14), pp. 6675-6681
dc.relation.uri https://doi.org/10.1021/jacs.0c00285
dc.rights © 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society , copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.0c00285 en_US
dc.subject enzyme activity en_US
dc.title Fabricating covalent organic framework capsules with commodious microenvironment for enzymes en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/jacs.0c00285
dc.contributor.sponsor National Natural Science Foundation of China en_US
dc.contributor.sponsor Tianjin Natural Science Foundation of China en_US
dc.relation.projectid 21871153 en_US
dc.relation.projectid 18JCZDJC37300 en_US
dc.date.embargoEndDate 2021-03-20
dc.embargo.terms 2021-03-20 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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