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The psychological impact of Stevens- Johnson syndrome and toxic epidermal necrolysis on patients' lives: a critically appraised topic

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Show simple item record O'Reilly, Pauline Kennedy, Catriona Meskell, Pauline Coffey, Alice Delaunois, I. Dore, Liz Howard, Siobhán Ramsay Bart Scanlon, C. Wilson, Donna M. Whelan, B. Ryan, S. 2020-04-17T12:45:25Z 2019
dc.identifier.issn 0007-0963
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 02/12/2020
dc.description.abstract A 65‐year‐old man presented with a 12‐h history of deteriorating rash. Two weeks previously he had completed a course of neoadjuvant chemotherapy for ductal carcinoma of the breast. On examination there were bullae, widespread atypical targetoid lesions and 15% epidermal detachment. There was no mucosal involvement on presentation, but subsequently it did evolve. Skin biopsy showed subepidermal blistering with epidermal necrosis. This confirmed our clinical diagnosis of overlap Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). On transfer to intensive care he was anxious and fearful. Management question What are the psychological impacts of SJS/TEN on this man's life? Background SJS and TEN have devastating outcomes for those affected. Objectives To conduct a Critically Appraised Topic to (i) analyse existing research related to the psychological impact of SJS and TEN and (ii) apply the results to the clinical scenario. Methods Seven electronic databases were searched for publications focusing on the psychological impact of SJS/TEN on adults over 18 years of age. Results Six studies met the inclusion criteria. Healthcare practitioners’ (HCPs’) lack of information around the disorder was highlighted. Patients experienced undue stress and fear. Some patients had symptoms aligned to post‐traumatic stress disorder (PTSD), anxiety and depression. Discussion and recommendation The evidence suggests that SJS and TEN impact psychologically on patients’ lives. Education of HCPs, to address their lack of awareness and information on SJS/TEN, should facilitate their capacity to provide information and support to patients, thereby reducing patient anxiety. On discharge, a follow‐up appointment with relevant HCPs to reduce the possibility of PTSD occurring should be considered. en_US
dc.language.iso eng en_US
dc.publisher Wiley and Sons Ltd en_US
dc.relation.ispartofseries British Journal of Dermatology;
dc.rights This is the peer reviewed version of the following article:The psychological impact of Stevens–Johnson syndrome and toxic epidermal necrolysis on patients’ lives: a Critically Appraised Topic P. O'Reilly C. Kennedy P. Meskell A. Coffey I. Delaunois L. Dore S. Howard B. Ramsay C. Scanlon D.M. Wilson B. Whelan S. Ryan British Journal of Dermatology which has been published in final form at . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en_US
dc.subject Stevens–Johnson syndrome en_US
dc.title The psychological impact of Stevens- Johnson syndrome and toxic epidermal necrolysis on patients' lives: a critically appraised topic en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2020-04-17T11:18:35Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1111/bjd.18746 2020-12-02
dc.embargo.terms 2020-12-02 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US
dc.internal.rssid 2942994
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle British Journal Of Dermatology
dc.description.status peer-reviewed

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