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Crystal growth kinetics of a metastable polymorph of tolbutamide in organic solvents

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dc.contributor.author Soto, Rodrigo
dc.contributor.author Verma, Vivek
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2020-04-17T10:54:08Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8731
dc.description peer-reviewed en_US
dc.description.abstract The crystal growth of tolbutamide (Form IL) in different solvents has been investigated by isothermal seeded desupersaturation experiments at different temperatures (268-283 K). Experimental data has been evaluated using empirical power law equations and the mechanistic based models: Burton-Cabrera-Frank (BCF) and Birth and Spread (B+S). The estimated activation energies and growth exponents suggest a surface integration controlled growth as confirmed separately by a mass transfer analysis. From the B+S model, the estimated solid-liquid interfacial energies and the mean diffusion distances on the surface ranged 1.23-1.90 mJ/m2 and 1-16 nm, respectively. The growth rate is strongly dependent on the solvent, decreasing in the order: acetonitrile > ethanol > ethyl acetate > n-propanol > toluene. The crystal growth becomes slower as the overall strength of the solute-solvent binding increases. This influence of the solvent corresponds very well with that found for nucleation of tolbutamide in the same solvents, and further supports the hypothesis that desolvation is an important step in crystallization. The similarity in the influence of the solvent on the kinetics of nucleation and growth very strongly supports the hypothesis that the solvent-solute interactions play an important role in the kinetics of formation of crystalline phases. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries Crystal Growth and Design;20 (3), pp. 1985-1996
dc.relation.uri https://doi.org/10.1021/acs.cgd.9b01637
dc.rights © 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.9b01637 en_US
dc.subject crystal growth en_US
dc.title Crystal growth kinetics of a metastable polymorph of tolbutamide in organic solvents en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acs.cgd.9b01637
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor ERC en_US
dc.relation.projectid 12/RC/2275_P2 en_US
dc.date.embargoEndDate 2021-01-22
dc.embargo.terms 2021-01-22 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2947491


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