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Mesenteric excision surgery or conservative limited resection in Crohn's disease: study protocol for an international, multicenter, randomized controlled trial

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dc.contributor.author Li, Yi
dc.contributor.author Mohan, Helen M.
dc.contributor.author Lan, Nan
dc.contributor.author Wu, Xiaojian
dc.contributor.author Gong, Jianfeng
dc.contributor.author Shen, Bo
dc.contributor.author Stocchi, Luca
dc.contributor.author Coffey, Calvin J.
dc.contributor.author Zhu, Weiming
dc.date.accessioned 2020-03-31T14:51:03Z
dc.date.available 2020-03-31T14:51:03Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8676
dc.description peer-reviewed en_US
dc.description.abstract BACKGROUND: The structures of the mesentery including adipose tissue, nerves, and lymphatics play an important role in the pathogenesis and disease progression of Crohn's disease (CD). Conventional surgical resection for CD usually does not involve resecting the mesentery en bloc with the specimen. This contrasts with complete mesocolic excision (CME) in colorectal cancer, which involves radical resection of the mesentery. Preliminary evidence from smaller studies suggests that applying the principle of mesocolic excision to CD surgery may reduce the risk of postoperative recurrence. This randomized controlled trial is designed to test whether applying the principles of mesocolic excision to CD results in reduced postoperative recurrence. It also aims to evaluate intra- and postoperative morbidity between the two approaches. METHODS: This international, multicenter, randomized controlled trial will randomize patients (n = 116) scheduled to undergo primary ileocolic resection to either receive extensive mesenteric excision (EME) or conventional ileocolic resection with limited mesenteric excision (LME). Five sites will recruit patients in three countries. In the EME group, the mesentery is resected following CME, while avoiding the root region, i.e., 1 cm from the root of the ileocolic artery and vein. In the LME group, the mesentery is retained, i.e., "close shave" or < 3 cm from the border of bowel. The primary end point will be surgical recurrence after surgery. The secondary end points will be the postoperative endoscopic and clinical recurrence, and intra- and postoperative morbidity. Demographics, risk factors, laboratory investigations, endoscopy, postoperative prophylaxis and imaging examination will be assessed. Analysis of the primary outcome will be on an intention-to-treat basis. DISCUSSION: If mesocolic excision in CD reduces postoperative disease recurrence and does not increase morbidity, this trial has the potential to change practice and reduce recurrence of CD after surgical resection. en_US
dc.language.iso eng en_US
dc.publisher BMC en_US
dc.relation.ispartofseries Trials;21:210
dc.relation.uri http://dx.doi.org/10.1186/s13063-020-4105-x
dc.subject Crohn’s disease en_US
dc.subject Ileocolic resection en_US
dc.subject mesentery en_US
dc.subject postoperative recurrence en_US
dc.title Mesenteric excision surgery or conservative limited resection in Crohn's disease: study protocol for an international, multicenter, randomized controlled trial en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1186/s13063-020-4105-x
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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