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Mechanics of human brain organoids

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dc.contributor.author Balbi, Valentina
dc.contributor.author Destrade, Michel
dc.contributor.author Goriely, Alain
dc.date.accessioned 2020-03-26T10:04:33Z
dc.date.available 2020-03-26T10:04:33Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8651
dc.description peer-reviewed en_US
dc.description.abstract Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex. Here we propose a mathematical model to elucidate the role played by two mechanisms which have been experimentally proven to be crucial in shaping human brain organoids: the contraction of the inner core of the organoid and the microstructural remodeling of its outer cortex. Our results show that both mechanisms are crucial for the final shape of the organoid and that perturbing those mechanisms can lead to pathological morphologies which are reminiscent of those associated with lissencephaly (smooth brain). en_US
dc.language.iso eng en_US
dc.publisher American Physical Society en_US
dc.relation.ispartofseries Physical Review E;101, 022403
dc.relation.uri https://dx.doi.org/10.1103/PhysRevE.101.022403
dc.subject organoids en_US
dc.subject prototypes en_US
dc.subject human organs en_US
dc.title Mechanics of human brain organoids en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1103/PhysRevE.101.022403
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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