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Formulating a stable mannitol infusion while maintaining hyperosmolarity

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dc.contributor.author Kavanagh, Oisín N.
dc.contributor.author Hogan, Fiona
dc.contributor.author Murphy, Caoimhe
dc.contributor.author Croker, Denise M.
dc.contributor.author Walker, Gavin M.
dc.date.accessioned 2020-03-23T14:24:55Z
dc.date.available 2020-03-23T14:24:55Z
dc.date.issued 2020
dc.identifier.issn 1999-4923
dc.identifier.uri http://hdl.handle.net/10344/8635
dc.description peer-reviewed en_US
dc.description.abstract Mannitol infusion is commonly used in the treatment of intracranial hypertension following traumatic brain injury. It has long been known to have stability issues, specifically, mannitol recrystallises from solutions greater than 10% w/v in ambient conditions. This can happen at any time, whether on the pharmacy shelf or during a medical procedure. This study describes the stability limits of 20% w/v mannitol infusion (the most common strength used clinically) and proposes a number of safer, stable and tuneable hyperosmotic formulations of mannitol in combination with clinically acceptable osmotic agents (NaCl, sorbitol and glycerol). en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Pharmaceutics;12 (2)
dc.subject Intracranial hypertension en_US
dc.subject mannitol en_US
dc.subject mannitol instability en_US
dc.subject raised intracranial pressure en_US
dc.subject recrystallisation en_US
dc.subject reformulation en_US
dc.subject traumatic brain injury en_US
dc.title Formulating a stable mannitol infusion while maintaining hyperosmolarity en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2020-03-23T14:19:12Z
dc.description.version PUBLISHED
dc.identifier.doi 10.3390/pharmaceutics12020187
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor ERC en_US
dc.relation.projectid 12/RC/2275 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2946331
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Pharmaceutics
dc.description.status peer-reviewed


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