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Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy†

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dc.contributor.author Cookman, Jennifer
dc.contributor.author Hamilton, Victoria
dc.contributor.author Price, Louise S.
dc.contributor.author Hall, Simon R.
dc.contributor.author Bangert, Ursel
dc.date.accessioned 2020-03-20T10:54:35Z
dc.date.available 2020-03-20T10:54:35Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8630
dc.description peer-reviewed en_US
dc.description.abstract Here, we show that the development of nuclei and subsequent growth of a molecular organic crystal system can be induced by electron beam irradiation by exploiting the radiation chemistry of the carrier solvent. The technique of Liquid Cell Electron Microscopy was used to probe the crystal growth of flufenamic acid; a current commercialised active pharmaceutical ingredient. This work demonstrates liquid phase electron microscopy analysis as an essential tool for assessing pharmaceutical crystal growth in their native environment while giving insight into polymorph identification of nano-crystals at their very inception. Possible mechanisms of crystal nucleation due to the electron beam with a focus on radiolysis are discussed along with the innovations this technique offers to the study of pharmaceutical crystals and other low contrast materials. en_US
dc.language.iso eng en_US
dc.publisher Royal Society of Chemistry en_US
dc.relation 736899 en_US
dc.relation.ispartofseries Nanoscale;12, pp. 4636–4644
dc.subject molecular crystalline en_US
dc.subject synthetic materials en_US
dc.title Visualising early-stage liquid phase organic crystal growth via liquid cell electron microscopy† en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1039/c9nr08126g
dc.contributor.sponsor European Union (EU) en_US
dc.contributor.sponsor EPRSC en_US
dc.relation.projectid 736899 en_US
dc.relation.projectid EP/G036780/1 en_US
dc.relation.projectid EP/L015544 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2947259


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