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Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum

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dc.contributor.author Hansena, Anne Marthe B
dc.contributor.author Wium, Cecilie
dc.contributor.author Lee, Sindre
dc.contributor.author Tierney, Audrey C.
dc.contributor.author McCarthy, Danielle
dc.contributor.author Roche, Helen M.
dc.contributor.author Drevon, Christian A.
dc.contributor.author Birkeland, Kåre I.
dc.contributor.author Gulseth, Hanne L.
dc.date.accessioned 2020-03-19T11:12:01Z
dc.date.available 2020-03-19T11:12:01Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8625
dc.description peer-reviewed en_US
dc.description.abstract Impaired insulin secretion and action are important for development of type 2 diabetes (T2D) and metabolic syndrome (MetS). Despite recognized heterogeneity of these glucometabolic disorders, few data are available of biological variation in insulin secretion and action among individuals with T2D and MetS. The aim of this study was to explore the inter-individual variations using gold standard methods in a cross-sectional study of two independent cohorts of phenotypically well-characterized subjects. Cohort I included 486 subjects with MetS, and cohort II 62 subjects with established T2D. First phase insulin secretion was defined as the incremental area under the curve 0–8 min (iAUC0–8 min) during an intravenous glucose tolerance test (IVGTT). Insulin sensitivity was measured as the insulin sensitivity index (SI) modelled from IVGTT in cohort I, and in II as total glucose disposal (TGD) estimated from a euglycaemic-hyperinsulinaemic clamp. Variation is given as total range and, fold-variation between 5%- and 95%-percentile. The iAUC0–8min ranged from 60 to 3397mUL 1min 1 among subjects with MetS and from 263 to 1194mUL 1min 1 in subjects with T2D, representing a more than 10-fold variation. Insulin sensitivity ranged from SI 0.19 to 15.29 (mU/L) 1min 1 among subjects with MetS and TGD 12.9–101.6 lmolkgFFM 1min 1 in subjects with T2D, representing a 6.8 and 5.5- fold variation, respectively. The other components of MetS; BMI, waist-hip ratio, HDL-cholesterol, triglycerides and blood pressure (BP), showed a 1.4–4.7-fold variation. In conclusion, our data demonstrated extensive inter-individual variations in insulin secretion and sensitivity. These variations may be essential to take into account when planning clinical research and treatment in subjects with T2D and MetS. en_US
dc.language.iso eng en_US
dc.publisher Taylor & Francis en_US
dc.relation.ispartofseries Scandinavian Journal of Clinical and Laboratory Investigation;
dc.subject Insulin secretion en_US
dc.subject insulin sensitivity en_US
dc.subject inter-individual variation en_US
dc.subject glucose tolerance en_US
dc.title Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1080/00365513.2020.1730433
dc.contributor.sponsor Norwegian Extra Foundation, the South- Eastern Norway Regional Health en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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