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Strategies for the treatment of Parkinson’s disease: beyond dopamine

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dc.contributor.author Iarkov, Alexandre
dc.contributor.author Barreto, George E.
dc.contributor.author Grizzell, Alex J.
dc.contributor.author Echeverria, Valentina
dc.date.accessioned 2020-03-13T12:44:05Z
dc.date.available 2020-03-13T12:44:05Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8615
dc.description peer-reviewed en_US
dc.description.abstract Parkinson’s disease (PD) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal α-synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This review discusses the physiological mechanisms involved in PD as well as new and prospective therapies for the disease. The current data suggest that prevention or early treatment of PD may be the most effective therapeutic strategy. New advances in the understanding of the underlyingmechanismsofPDpredictthedevelopmentofmorepersonalizedandintegral therapies in the years to come. Thus, the development of more reliable biomarkers at asymptomatic stages of the disease, and the use of genetic profiling of patients will surely permit a more effective treatment of PD. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Aging Neuroscience;12, article 4
dc.relation.uri http://dx.doi.org/10.3389/fnagi.2020.00004
dc.rights First published by Frontiers Media en_US
dc.subject gene therapy en_US
dc.subject prevention en_US
dc.subject cotinine en_US
dc.subject stem cells en_US
dc.subject precision medicine en_US
dc.title Strategies for the treatment of Parkinson’s disease: beyond dopamine en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3389/fnagi.2020.00004
dc.contributor.sponsor Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica en_US
dc.relation.projectid 1190264 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2949089


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