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Laser induced periodic surface structures enhance neuroelectrode charge transfer capability and modulate astrocyte function in vitro

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dc.contributor.author Kelly, Adriona
dc.contributor.author Farid, Nazar
dc.contributor.author Krukiewicz, Katarzyna
dc.contributor.author Belisle, Nicole
dc.contributor.author Groarke, John
dc.contributor.author Waters, Elaine
dc.contributor.author Trotier, Alexandre
dc.contributor.author Laffir, Fathima R.
dc.contributor.author Kilcoyne, Michelle
dc.contributor.author O'Connor, Gerard M.
dc.contributor.author Biggs, Manus J.
dc.date.accessioned 2020-03-09T09:47:13Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/8604
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 22/01/2021
dc.description.abstract The brain machine interface (BMI) describes a group of technologies capable of communicating with excitable nervous tissue within the central nervous system (CNS). BMI’s have seen major advances in recent years but these advances have been impeded due to a temporal deterioration in the signal to noise ratio of recording electrodes following insertion into the CNS. This deterioration has been attributed to an intrinsic host tissue response, namely reactive gliosis which involves a complex series of immune mediators resulting in implant encapsulation via the synthesis of proinflammatory signaling molecules and the recruitment of glial cells. There is a clinical need to reduce tissue encapsulation in situ and improve long-term neuroelectrode functionality. Physical modification of the electrode surface at the nanoscale could satisfy these requirements by integrating electrochemical and topographical signals to modulate neural cell behavior. In this study, commercially available platinum iridium (Pt/Ir) microelectrode probes were nanotopographically (NT) functionalized using femto/picosecond laser processing to generate laser induced periodic surface structures (LIPSS). Three different topographies and their physical properties were assessed by scanning electron microscopy and atomic force microscopy. The electrochemical properties of these interfaces were investigated using electrochemical impedance spectroscopy and cyclic voltammetry. The in vitro response of mixed cortical cultures (embryonic rat E14/E17), was subsequently assessed by confocal microscopy, ELISA and multiplex protein array analysis. Overall LIPSS features improved the electrochemical properties of the electrodes, promoted cell alignment and modulated the expression of multiple ion channels involved in key neuronal functions. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 13RC2073 en_US
dc.relation.ispartofseries ACS Biomaterials Science and Engineering;6, (3), pp. 1449-1461
dc.relation.uri https://doi.org/10.1021/acsbiomaterials.9b01321
dc.rights © 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal Title, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsbiomaterials.9b01321 en_US
dc.subject neuroelectrode en_US
dc.subject platinum/iridium en_US
dc.subject LIPSS cell alignment en_US
dc.subject astrogliosis en_US
dc.subject electrochemical impedance en_US
dc.title Laser induced periodic surface structures enhance neuroelectrode charge transfer capability and modulate astrocyte function in vitro en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acsbiomaterials.9b01321
dc.contributor.sponsor SFI en_US
dc.relation.projectid 11/SIRG/B2135 en_US
dc.relation.projectid 13/RC/2073 en_US
dc.date.embargoEndDate 2021-01-22
dc.embargo.terms 2021-01-22 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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