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Forty years since the structural elucidation of platelet-activating factor (PAF): historical current and future research perspectives

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dc.contributor.author Lordan, Ronan
dc.contributor.author Tsoupras, Alexandros
dc.contributor.author Zabetakis, Ioannis
dc.contributor.author Demopoulos, Constantinos A.
dc.date.accessioned 2020-03-02T11:35:52Z
dc.date.available 2020-03-02T11:35:52Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/8584
dc.description peer-reviewed en_US
dc.description.abstract In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced histamine release from rabbit platelets producing antibodies in passive cutaneous anaphylaxis. Henson described a ‘soluble factor’ released from leukocytes that induced vasoactive amine release in platelets. Later observations by Siraganuan and Osler observed the existence of a diluted substance that had the capacity to cause platelet activation. In 1972, the term platelet-activating factor (PAF) was coined by Benveniste, Henson, and Cochrane. The structure of PAF was later elucidated by Demopoulos, Pinckard, and Hanahan in 1979. These studies introduced the research world to PAF, which is now recognised as a potent phospholipid mediator. Since its introduction to the literature, research on PAF has grown due to interest in its vital cell signalling functions and more sinisterly its role as a pro-inflammatory molecule in several chronic diseases including cardiovascular disease and cancer. As it is forty years since the structural elucidation of PAF, the aim of this review is to provide a historical account of the discovery of PAF and to provide a general overview of current and future perspectives on PAF research in physiology and pathophysiology. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Molecules;24, 4414
dc.subject platelet-activating factor en_US
dc.subject inflammation en_US
dc.subject cardiovascular disease en_US
dc.subject cell signalling en_US
dc.subject phospholipids en_US
dc.title Forty years since the structural elucidation of platelet-activating factor (PAF): historical current and future research perspectives en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/molecules24234414
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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