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Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds

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dc.contributor.author Hidalgo-Lanussa Oscar
dc.contributor.author Baez-Jurado Eliana
dc.contributor.author Echeverria, Valentina
dc.contributor.author Ashraf Ghulam
dc.contributor.author Sahebkar, Amirhossein
dc.contributor.author Garcia-Segura Luis Miguel
dc.contributor.author Melcangi, Roberto C.
dc.contributor.author Barreto, George E.
dc.date.accessioned 2020-01-24T11:36:38Z
dc.date.issued 2019
dc.identifier.citation Hidalgo-Lanussa O, Baez-Jurado E, Echeverria V, Ashraf GM, Sahebkar A, Garcia-Segura LM, Melcangi RC, Barreto GE (2019) 'Lipotoxicity, neuroinflammation, glial cells and estrogenic compounds'. Journal Of Neuroendocrinology, . en_US
dc.identifier.uri http://hdl.handle.net/10344/8421
dc.description peer-reviewed en_US
dc.description.abstract The high concentrations of free fatty acids as a consequence of obesity and overweight have become risk factors for the development of different diseases including neurodegenerative ailments. Free fatty acids (FAs) are strongly related to inflammatory events, causing cellular and tissue alterations in the brain, including cell death, deficits in neurogenesis and gliogenesis and cognitive decline. It has been reported that people with a high body mass index have a higher risk of suffering from Alzheimer's disease. Hormones such as estradiol not only have beneficial effects on brain tissue but also exert some adverse effects on peripheral tissues including the ovary and breast. For this reason, some studies have evaluated the protective effect of estrogen receptor (ER) agonists with more specific tissue activities, such as the neuroactive steroid tibolone. Activation of ERs positively affects the expression of pro-survival factors and cell signaling pathways, thus promoting cell survival. This review aims to discuss the relationship between lipotoxicity and the development of neurodegenerative diseases. We also elaborate on the cellular and molecular mechanisms involved in neuroprotection induced by estrogens. en_US
dc.language.iso eng en_US
dc.publisher Wiley and Sons Ltd en_US
dc.relation.ispartofseries Journal of Neuroendocrinology;32 (1) e12776
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12776
dc.relation.uri http://dx.doi.org/10.1111/jne.12776
dc.rights This is the author accepted peer reviewed version of the following article Journal of Neuroendocrinology 2019, 32 (1), e12776 Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds Oscar Hidalgo‐Lanussa Eliana Baez‐Jurado Valentina Echeverria Ghulam Md Ashraf Amirhossein Sahebkar Luis Miguel Garcia‐Segura Roberto C. Melcangi George E. Barreto:, which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms en_US
dc.subject estrogens en_US
dc.subject obesity en_US
dc.subject neurodegenerative diseases en_US
dc.subject microglia en_US
dc.subject neurosteroids en_US
dc.subject lipotoxicity en_US
dc.title Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2020-01-24T11:25:57Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1111/jne.12776
dc.date.embargoEndDate 2020-07-23
dc.embargo.terms 2020-07-23 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2921430
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Journal Of Neuroendocrinology
dc.description.status peer-reviewed


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