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The association between smoking and gut microbiome in Bangladesh

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dc.contributor.author Nolan-Kenney, Rachel
dc.contributor.author Wu, Fen
dc.contributor.author Hu, Jiyuan
dc.contributor.author Yang, Liying
dc.contributor.author Kelly, Dervla
dc.contributor.author Li, Huilin
dc.contributor.author Jasmine, Farzana
dc.contributor.author Kibriya, Muhammad G.
dc.contributor.author Parvez, Faruque
dc.contributor.author Shaheen, Ishrat
dc.contributor.author Sarwar, Golam
dc.contributor.author Ahmed, Alauddin
dc.contributor.author Eunus, Mahbub
dc.contributor.author Islam, Tariqul
dc.contributor.author Pei, Zhiheng
dc.contributor.author Ahsan, Habibul
dc.contributor.author Chen, Yu
dc.date.accessioned 2020-01-15T16:25:17Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/8380
dc.description peer-reviewed en_US
dc.description.abstract Introduction Epidemiological studies that investigate alterations in the gut microbial composition associated with smoking are lacking. This study examined the composition of the gut microbiome in smokers compared with non-smokers. Methods Stool samples were collected in a cross-sectional study of 249 participants selected from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Microbial DNA was extracted from the fecal samples and sequenced by 16S rRNA gene sequencing. The associations of smoking status and intensity of smoking with the relative abundance or the absence and presence of individual bacterial taxon from phylum to genus levels were examined. Results The relative abundance of bacterial taxa along the Erysipelotrichi-to-Catenibacterium lineage was significantly higher in current smokers compared to never smokers. The odds ratio comparing the mean relative abundance in current smokers with that in never smokers was 1.91 (95% confidence interval [CI] = 1.36 to 2.69) for the genus Catenibacterium and 1.89 (95% CI = 1.39 to 2.56) for the family Erysipelotrichaceae, the order Erysipelotrichale, and the class Erysipelotrichi ((FDR-adjusted p-values = 0.0008 to 0.01). A dose-response association was observed for each of these bacterial taxa. The presence of Alphaproteobacteria was significantly greater comparing current with never smokers (OR = 4.85, FDR-adjusted p-values = 0.04). Conclusions Our data in a Bangladeshi population are consistent with evidence of an association between smoking status and dosage with change in the gut bacterial composition. Implications This study for the first time examined the relationship between smoking and the gut microbiome composition. The data suggest that smoking status may play an important role in the composition of the gut microbiome, especially among individuals with higher levels of tobacco exposure. en_US
dc.language.iso eng en_US
dc.publisher Oxford University Press
dc.relation.ispartofseries Nicotine and Tobacco Research: 22 (8), pp. 1339-1346
dc.relation.uri https://doi.org/10.1093/ntr/ntz220
dc.rights This is a pre-copyedited, author-produced PDF of an article accepted for publication in Nicotine and Tobacco Research following peer review. The version of record [insert complete citation information here] is available online at: https://doi.org/10.1093/ntr/ntz220 en_US
dc.subject HEALS en_US
dc.subject microbial composition en_US
dc.subject smoking dosage en_US
dc.subject smoking status en_US
dc.subject relative abundance en_US
dc.title The association between smoking and gut microbiome in Bangladesh en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1093/ntr/ntz220
dc.date.embargoEndDate 2020-12-03
dc.embargo.terms 2020-12-03 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2963168


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