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Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty

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dc.contributor.author Anand-Ivell, Ravinder
dc.contributor.author Byrne, Colin J.
dc.contributor.author Arnecke, Jonas
dc.contributor.author Fair, Seán
dc.contributor.author Lonergan, Patrick
dc.contributor.author Kenny, David A.
dc.contributor.author Ivell, Richard
dc.date.accessioned 2019-12-05T09:04:08Z
dc.date.available 2019-12-05T09:04:08Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/8296
dc.description peer-reviewed en_US
dc.description.abstract Leydig cell functional capacity reflects the numbers and differentiation status of the steroidogenic Leydig cells in the testes and becomes more or less fixed in early adulthood with the final establishment of the hypothalamo-pituitary-gonadal (HPG) axis after puberty. Factors influencing Leydig cell functional capacity and its role in puberty are poorly understood. Using a bovine model of dairy bulls fed four different nutritional regimes from 1 month to 12 months, and applying circulating Insulin-like peptide 3 (INSL3) as an accurate biomarker of Leydig cell functional capacity, showed that a high plane of nutrition in the first 6 months of life, but not later, significantly increased INSL3 in young adulthood. Moreover, INSL3 concentration at 4 months indicated a marked differential in early feeding regime and correlated well (negatively) with the timing of puberty, as reflected by the age in days for the first production of an ejaculate with >50 million sperm and >10% forward motility, as well as with testis size at 18 months. Reversing the diet at 6 months was unable to rectify the trend in either parameter, unlike for other parameters such as testosterone, body weight, and scrotal circumference. This study has shown that early prepubertal nutrition is a key factor in the development of Leydig cell functional capacity in early adulthood and appears to be a key driver in the dynamic progression of puberty. en_US
dc.language.iso eng en_US
dc.publisher Public Library of Science en_US
dc.relation.ispartofseries PLoS One:0225465
dc.subject Leydig cells en_US
dc.subject peptide hormone en_US
dc.title Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1371/journal.pone.0225465
dc.contributor.sponsor Irish Department of Agriculture, Food and Marine Research en_US
dc.relation.projectid 11/S/116
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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