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Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review

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dc.contributor.author Naderi, Yazdan
dc.contributor.author Panahi, Yunes
dc.contributor.author Barreto, George E.
dc.contributor.author Sahebkar, Amirhossein
dc.date.accessioned 2019-11-27T11:27:51Z
dc.date.available 2019-11-27T11:27:51Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/8267
dc.description peer-reviewed en_US
dc.description.abstract To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group. Written in languages other than English; duplicate data; in vitro studies and combination of minocycline with other neuroprotective agents were excluded. Neurological function of patients was assessed by National Institute of Health Stroke Scale, modified Rankin Scale, and modified Barthel Index. Neuroprotective effects were assessed by detecting the expression of inflammatory cytokines. We examined 35 papers concerning the protective effects of minocycline in focal cerebral ischemia in animal models and 6 clinical trials which had evaluated the neuroprotective effects of minocycline in ischemic stroke. These studies revealed that minocycline increases the viability of neurons and decreases the infarct volume following cerebral ischemia. The mechanisms that were reported in these studies included anti-inflammatory, antioxidant, as well as anti-apoptotic effects. Minocycline also increases the neuronal regeneration following cerebral ischemia. Minocycline has considerable neuroprotective effects against cerebral ischemia-induced neuronal damages. However, larger clinical trials may be required before using minocycline as a neuroprotective drug in ischemic stroke. en_US
dc.language.iso eng en_US
dc.publisher Medknow Publications en_US
dc.relation.ispartofseries Neural Regeneration Research;15(5),pp. 773-782
dc.subject ischemic stroke en_US
dc.subject minocycline en_US
dc.subject neuronal regeneration en_US
dc.subject neuroprotection en_US
dc.title Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.4103/1673-5374.268898
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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