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Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery:In vitro evidence

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Show simple item record Pederzoli, Francesca Ruozi, Barbara Duskey, Jason T. Hagmeyer, Simone Sauer, Ann Katrin Grabrucker, Stefanie Coelho, Romina Oddone, Natalia Ottonelli, Ilaria Daini, Eleonora Zoli, Michele Vandelli, Maria Angela Tosi, Giovanni Grabrucker, Andreas M. 2019-11-12T11:55:19Z 2019-11-12T11:55:19Z 2019
dc.description peer-reviewed en_US
dc.description.abstract The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability to cross the blood–brain barrier. In this work, we study the possibility of adopting nanomedicine to overcome KLVFF limits in biodistribution. We produced new engineered polymeric nanoparticles (NPs), and we evaluated the cellular toxicity of these NPs and validated that KVLFF peptides released by NPs show the same promising effects on AD pathology. Our results revealed the successful generation of KVLFF loaded NPs that, without significant effects on cell heath, are even more potent in reversing Aβ-induced pathologies compared to the free peptide. Therefore, NPs will significantly advance KVLFF treatment as a therapeutic option for AD. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation MEACI en_US
dc.relation.ispartofseries Pharmaceutics;11, 572
dc.subject Alzheimer’s disease en_US
dc.subject polymeric nanoparticles en_US
dc.subject KLVFF peptide en_US
dc.subject blood-brain barrier en_US
dc.title Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery:In vitro evidence en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/pharmaceutics11110572
dc.contributor.sponsor UNIMORE en_US
dc.contributor.sponsor MEACI en_US
dc.contributor.sponsor Evangelisches Studienwerk Villigst e.V. en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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