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Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005–2016

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dc.contributor.author Calderon, Mauricio Giusti
dc.contributor.author de Sousa Santos, Edige Felipe
dc.contributor.author de Abreu, Luiz Carlos
dc.contributor.author Rodrigo Daminello Raimundo
dc.date.accessioned 2019-11-07T10:00:28Z
dc.date.available 2019-11-07T10:00:28Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/8210
dc.description peer-reviewed en_US
dc.description.abstract To estimate the gastroschisis seasonality and trend of prevalence in recent years, stratified by maternal age and geographical clusters of São Paulo state, a population–based study was designed. We used data from the Live Births Information System (SINASC) in São Paulo state, Brazil, from 2005 to 2016. Trends of prevalence were evaluated for the specific subgroups using the Prais–Winsten regression model, and the Durbin–Watson test was used, to estimate the regression coefficient, the annual percent change (APC), and 95% confidence interval (CI). We observed 1576 cases of gastroschisis among 7,317,657 live births (LB), a prevalence of 2.154 (95% CI: 2.047–2.260) per 10,000 LB which included, 50.6% males, 67.4% Caucasians, 53.4% preterm births, and 80.9% caesarean births. The prevalence of gastroschisis significantly increased by 2.6% (95% CI: 0.0–5.2) per year, and this trend was higher in mothers aged 30–34 years (APC: 10.2, 95% CI: 1.4–19.4) than in mothers of other age groups. Between 2011 and 2016, we identified the existence of seasonality based on the date of conception in the middle months of the year (p = 0.002). This is the first and largest population–based study summarizing current epidemiology and identifying trend of prevalence of gastroschisis in São Paulo state. en_US
dc.language.iso eng en_US
dc.publisher Nature Ressearch en_US
dc.relation.ispartofseries Scientific Reports;9,14491
dc.subject Gastroschisis en_US
dc.subject paraumbilical herniation en_US
dc.subject dietary factors en_US
dc.title Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005–2016 en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1038/s41598-019-50935-1
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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