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Effect of impeller design on homogeneity, size and strength of pharmaceutical granules produced by high-shear wet granulation

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dc.contributor.author Mangwandi, Chirangano
dc.contributor.author Mirza, Zakaria
dc.contributor.author Liu, Jiang T.
dc.contributor.author Glocheux, Yoann
dc.date.accessioned 2019-05-24T14:36:56Z
dc.date.available 2019-05-24T14:36:56Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10344/7862
dc.description peer-reviewed en_US
dc.description.abstract Small mixer impeller design is not tailored for granulation because impellers are intended for a wide range of processes. The aim of this research was to evaluate the performances of several impellers to provide guidance on the selection and design for the purposes of granulation. Lactose granules were produced using wet granulation with water as a binder. A Kenwood KM070 mixer was used as a standard apparatus and five impeller designs with different shapes and surface areas were used. The efficacy of granulate formation was measured by adding an optically sensitive tracer to determine variations in active ingredient content across random samples of granules from the same size classes. It was found that impeller design influenced the homogeneity of the granules and therefore can affect final product performance. The variation in active ingredient content across granules of differing size was also investigated. The results show that small granules were more potent than larger granules. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Particuology;23, pp. 31-39
dc.relation.uri https://doi.org/10.1016/j.partic.2014.12.009
dc.rights This is the author’s version of a work that was accepted for publication in Particuology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Particuology, 2015, 23, pp. 31-39, https://doi.org/10.1016/j.partic.2014.12.009 en_US
dc.subject granule strength en_US
dc.subject impeller design en_US
dc.subject homogeneity en_US
dc.subject high-shear granulation en_US
dc.subject lactose monohydrate en_US
dc.title Effect of impeller design on homogeneity, size and strength of pharmaceutical granules produced by high-shear wet granulation en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.partic.2014.12.009
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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