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Reelin: Diverse roles in central nervous system development, health and disease

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dc.contributor.author Armstrong, Nicholas C.
dc.contributor.author Anderson, Rebecca C.
dc.contributor.author McDermott, Kieran W.
dc.date.accessioned 2019-05-13T12:03:31Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/7830
dc.description peer-reviewed en_US
dc.description.abstract Over the past 20 years the structure and function of Reelin, an extracellular glycoprotein with a role in cell migration and positioning during development has been elucidated. Originally discovered in mice exhibiting a peculiar gait and hypoplastic cerebellar tissue, Reelin is secreted from Cajal-Retzius neurons during embryonic life and has been shown to act as a stop signal, guiding migrating radial neurons in a gradient-dependent manner. Reelin carries out its function by binding to the receptors, very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) resulting in the phosphorylation of the intracellular protein Disabled-1 (Dab-1) which is essential for effective Reelin signaling. Abnormalities in the RELN gene can result in multiple unusual structural outcomes including disruption of cortical layers, heterotopia, polymicrogyria and lissencephaly. Recent research has suggested a potential role for Reelin in the pathogenesis of neurological diseases such as schizophrenia, autism and Alzheimer’s disease. This short review will address the current understanding of the structure and function of this protein and its emerging role in the development of neurological disorders. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries The International Journal of Biochemistry & Cell Biology;112, pp. 72-75
dc.relation.uri https://doi.org/10.1016/j.biocel.2019.04.009
dc.rights This is the author’s version of a work that was accepted for publication in The International Journal of Biochemistry and Cell Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Interntional Journal of Biochemistry and Cell Biology, 2019, 112, pp.72-75., https://doi.org/10.1016/j.biocel.2019.04.009 en_US
dc.subject Reelin en_US
dc.subject cortical migration en_US
dc.subject schizophrenia en_US
dc.subject lamination en_US
dc.subject Cajal-Retzius neurons en_US
dc.title Reelin: Diverse roles in central nervous system development, health and disease en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.biocel.2019.04.009
dc.date.embargoEndDate 2020-04-22
dc.embargo.terms 2020-04-22 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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