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The biological mechanisms regulating sperm selection by the ovine cervix

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Show simple item record Fair, Seán Meade, Kieran G. Reynaud, K. Druart, X. de Graaf, S.P. 2019-05-08T13:50:10Z 2019
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 07/07/2020
dc.description.abstract In species where semen is deposited in the vagina, the cervix has the unique function of facilitating progress of spermatozoa towards the site of fertilisation while also preventing the ascending influx of pathogens from the vagina. For the majority of species, advances in assisted reproduction techniques facilitate the bypassing of the cervix and therefore its effect on the transit of processed spermatozoa has been largely overlooked. The exception is in sheep, as it is currently not possible to traverse the ovine cervix with an inseminating catheter due to it's complex anatomy, and semen must be deposited at the external cervical os. This results in unacceptably low pregnancy rates when frozen-thawed or liquid stored (>24h) semen is inseminated. The objective of this review, is to discuss the biological mechanisms which regulate cervical sperm selection. We assess the effects of endogenous and exogenous hormones on cervical mucus composition and discuss how increased mucus production and flow during oestrus stimulates sperm rheotaxis along the crypts and folds of the cervix. Emerging results shedding light on the sperm-cervical mucus interaction as well as the dialogue between spermatozoa and the innate immune system are outlined. Finally, ewe breed differences in cervical function and the impact of semen processing on the success of fertilisation, as well as the most fruitful avenues of further investigation in this area are proposed. en_US
dc.language.iso eng en_US
dc.publisher BioScientifica: Society for Reproduction and Fertility en_US
dc.relation 16/RD/SusAn/ERA562 en_US
dc.relation.ispartofseries Reproduction;158 (1), pp. R!-R13
dc.rights This manuscript has been accepted for publication in Reproduction but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at 2019 of publication en_US
dc.subject ovine cervix en_US
dc.subject sperm en_US
dc.title The biological mechanisms regulating sperm selection by the ovine cervix en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1530/REP-18-0595
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor Australian Wool Innovation en_US
dc.contributor.sponsor NSW Stud Merino Breeders’ Association Trust en_US
dc.relation.projectid 16/RD/SusAn/ERA562 en_US
dc.relation.projectid 563 00252 en_US 2020-07-01
dc.embargo.terms 2020-07-01 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US

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