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Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

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dc.contributor.author Duffy, David J.
dc.contributor.author Schnitzler, Christine
dc.contributor.author Karpinski, Lorraine
dc.contributor.author Thomas, Rachel
dc.contributor.author Whilde, Jenny
dc.contributor.author Eastman, Catherine
dc.contributor.author Yang, Calvin
dc.contributor.author Krstic, Aleksandar
dc.contributor.author Rollinson, Devon
dc.contributor.author Zirkelbach, Bette
dc.contributor.author Yetsko, Kelsey
dc.contributor.author Burkhalter, Brooke
dc.contributor.author Martindale, Mark Q.
dc.date.accessioned 2019-04-04T10:45:25Z
dc.date.available 2019-04-04T10:45:25Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/7744
dc.description peer-reviewed en_US
dc.description.abstract Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are required to help maintain healthy populations until the chronic underlying causes of these issues can be addressed. Fibropapillomatosis in sea turtles is one such wildlife disease. Here, we applied precision-medicine-based approaches to profile fibropapillomatosis tumors to better understand their biology, identify novel therapeutics, and gain insights into viral and environmental triggers for fibropapillomatosis. We show that fibropapillomatosis tumors share genetic vulnerabilities with human cancer types, revealing that they are amenable to treatment with human anti-cancer therapeutics. en_US
dc.language.iso eng en_US
dc.publisher Nature Research en_US
dc.relation 663830-BU115 en_US
dc.relation.ispartofseries Communications Biology;1:63
dc.relation.uri http://dx.doi.org/10.1038/s42003-018-0059-x
dc.subject wildlife populations en_US
dc.subject sea turtle en_US
dc.title Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1038/s42003-018-0059-x
dc.contributor.sponsor Save Our Seas Foundation en_US
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor National Science Foundation en_US
dc.relation.projectid SOSF356 en_US
dc.relation.projectid 17-033R en_US
dc.relation.projectid 663830-BU115 en_US
dc.relation.projectid DBI-1560356 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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