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Self-assembled cationic #-cyclodextrin nanostructures for siRNA delivery

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dc.contributor.author Singh, Raghvendra Pratap
dc.contributor.author Hidalgo, Tania
dc.contributor.author Cazade, Pierre-André
dc.contributor.author Darcy, Raphael
dc.contributor.author Cronin, Michael
dc.contributor.author Dorin, Irina
dc.contributor.author O'Driscoll, Caitrionia M.
dc.contributor.author Thompson, Damien
dc.date.accessioned 2019-03-13T15:29:36Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/7694
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 5/02/2019
dc.description.abstract Functionalized cyclodextrin molecules assemble into a wide variety of superstructures in solution, which are of interest for drug delivery and other nanomaterial and biomaterial applications. Here we use a combined simulation and experimental approach to probe the coassembly of siRNA and cationic cyclodextrin (c-CD) derivatives into a highly stable gene delivery nanostructure. The c-CD form supramolecular structures via interdigitation of their aliphatic tails, analogous to the formation of lipid bilayers and micelles. The native conformation of siRNA is preserved by the encapsulating c-CD superstructure in an extensive hydrogen-bonding network between the positively charged side arms of c-CD and the negatively charged siRNA backbone. The stability of the complexation is confirmed using isothermal titration calorimetry, and the experimental/simulation codesign methodology opens new avenues for creation of highly engineerable gene delivery vectors. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation 713690 en_US
dc.relation.ispartofseries Molecular Pharmaceutics;16 (3), pp. 1358-1366
dc.relation.uri http://dx.doi.org/10.1021/acs.molpharmaceut.8b01307
dc.rights © 2019 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see en_US
dc.subject cyclodextrin en_US
dc.subject gene delivery en_US
dc.subject molecular dynamics en_US
dc.subject self-assembly en_US
dc.subject siRNA en_US
dc.title Self-assembled cationic #-cyclodextrin nanostructures for siRNA delivery en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1021/acs.molpharmaceut.8b01307
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor HEA en_US
dc.contributor.sponsor EI en_US
dc.contributor.sponsor ERC en_US
dc.relation.projectid 13/RC/2073 en_US
dc.relation.projectid 15/CDA/3491 en_US
dc.relation.projectid 713690 en_US
dc.date.embargoEndDate 2020-02-05
dc.embargo.terms 2020-02-05 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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