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Rapid microwave assisted synthesis and characterisation of a semiconducting polymer with pKa tuneable degradation properties

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dc.contributor.author Heffernan, Maria M.
dc.contributor.author O'Reilly, Emmet J.
dc.date.accessioned 2019-03-04T12:52:17Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/10344/7650
dc.description peer-reviewed en_US
dc.description The full text of this article will not be available in ULIR until the embargo expires on the 20/02/2021
dc.description.abstract As part of ongoing efforts to develop electroactive polymers (EAPs) which are biodegradable/bioresorbable, we report on the microwave assisted synthesis and characterization of an electrically conducting and electroactive polymer that capitalises on pKa sensitivity to initiate the system’s fracture and breakdown. The system, poly(bis((thiophen-2-yl) methylene) benzene-1,4-diamine), a poly(thiophene-azomethine) co-polymer (PAZO), incorporates hydrolytically sensitive azomethine linkers amongst bithiophene units resulting in one continuously conjugated and redox-active macromolecular framework. Rapid microwave assisted synthesis allowed for facile preparation of the polymer with significantly reduced reaction times when compared to traditional synthetic routes. Electrochemical analysis indicated quasi-reversible electrochemical behaviour with sufficiently high conductivity for in vivo biomedical applications. The polymer displays tunable degradation behaviour whereby the time duration required for polymeric breakdown is a function of the pKa of the acid used to catalyse the reaction resulting in controllable degradation times ranging from 1 h to 6 months. The development of conductive polymeric materials that are fully degradable over pre-defined time periods opens up a portal to the next generation of EAPs for in vivo biomedical applications. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries European Polymer Journal;114, pp. 206-212
dc.relation.uri https://doi.org/10.1016/j.eurpolymj.2019.02.005
dc.rights This is the author’s version of a work that was accepted for publication in European Polymer Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Polymer Journal, 2019, 114, pp. 206-212, https://doi.org/10.1016/j.eurpolymj.2019.02.005 en_US
dc.subject electroactive polymers en_US
dc.subject hydrolysis en_US
dc.title Rapid microwave assisted synthesis and characterisation of a semiconducting polymer with pKa tuneable degradation properties en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.eurpolymj.2019.02.005
dc.date.embargoEndDate 2021-02-20
dc.embargo.terms 2021-02-20 en_US
dc.rights.accessrights info:eu-repo/semantics/embargoedAccess en_US


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